Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684543 | 0.86 | ALDH1A1 (0.56) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5355290 | 0.86 | ALDH1A1 (0.56) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5345276 | 0.85 | HRH3 (0.48) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5345280 | 0.85 | HRH3 (0.48) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5258765 | 0.85 | CTSB (0.39) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5349843 | 0.84 | HRH3 (0.50) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5256266 | 0.84 | PDGFRB (0.47) | HRH3ALDH1A1KDM4EMAPTEPHX2 | |
| SCHEMBL8298316 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL14356164 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2GAAHRH3ALDH1A1KDM4E | |
| SCHEMBL5350931 | 0.80 | CTSB (0.46) | SMN1; SMN2ALDH1A1CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | claimed |
| US-20040248949-A1 | Benzamide nitriles | ROCHE PALO ALTO LLC | 2004-12-09 | — | — | US | claimed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248949-A1 | Benzamide nitriles | CTSK, CTSS, CMA1 | SMN1; SMN2 524/4885GAA 27/4885HRH3 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.