Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5348225 | 0.90 | ALDH1A1 (0.60) | KMT2AMEN1POLBSMN1; SMN2EPHX2 | |
| SCHEMBL968903 | 0.82 | POLB (0.71) | KMT2AMEN1POLBMAPTSMN1; SMN2 | |
| SCHEMBL17883406 | 0.81 | KMT2A (0.50) | KMT2AMEN1POLBSMN1; SMN2EPHX2 | |
| SCHEMBL17778393 | 0.81 | MAPT (0.71) | KMT2AMEN1POLBMAPTSMN1; SMN2 | |
| SCHEMBL7497341 | 0.81 | LMNA (0.66) | KMT2AMEN1POLBSMN1; SMN2EPHX2 | |
| SCHEMBL5356584 | 0.79 | SMN1; SMN2 (0.73) | POLBSMN1; SMN2EPHX2NOTUMALDH1A1 | |
| SCHEMBL304802 | 0.78 | TDP1 (0.60) | KMT2ANAMPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL2198042 | 0.78 | EPHX2 (0.69) | SMN1; SMN2EPHX2NAMPTNOTUMALDH1A1 | |
| SCHEMBL30420372 | 0.78 | EPHX2 (0.69) | SMN1; SMN2EPHX2NAMPTNOTUMALDH1A1 | |
| SCHEMBL16398136 | 0.77 | MAPT (0.67) | KMT2AMEN1POLBMAPTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160902-B2 | Amide derivatives and methods of their use | ADOLOR CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |
| WO-2005049564-A1 | AMIDE DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
| US-20050107355-A1 | Amide derivatives and methods of their use | CUBIST PHARMACEUTICALS, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107355-A1 | Amide derivatives and methods of their use | HRH2, SLC10A2, ALPI | KMT2A 3693/4885MEN1 4308/4885POLB 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.