SCHEMBL5347477

SCHEMBL5347477

Cc1cc(Cl)c(-c2ccccn2)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 3/20 0.55
CCR5 P51681 3/20 0.55
CCR8 P51685 3/20 0.55
KDM4E B2RXH2 8/20 0.50
METAP1 P53582 3/20 0.50
LMNA P02545 3/20 0.50
CYP1A2 P05177 1/20 0.50
POLB P06746 1/20 0.50
BLM P54132 1/20 0.50
HIF1A Q16665 1/20 0.50
DOHH Q9BU89 1/20 0.50
P4HTM Q9NXG6 1/20 0.50
TDP1 Q9NUW8 2/20 0.48
NPC1 O15118 5/20 0.47
METAP2 P50579 1/20 0.45
FFAR1 O14842 1/20 0.44
GRM5 P41594 2/20 0.44
CBFB Q13951 1/20 0.44
TP53 P04637 5/20 0.43
RAB9A P51151 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31175944 0.84 CCR1 (0.55) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL5328683 0.79 CCR1 (0.50) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL28001914 0.79 NPC1 (0.50) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL3612264 0.79 KDM4E (0.55) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL29633944 0.79 KDM4E (0.55) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL5325012 0.79 KDM4E (0.59) CCR1CCR5CCR8KDM4EMETAP1
Ether SCHEMBL28146636 0.77 CCR1 (0.51) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL12164875 0.76 KDM4E (0.46) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL9585297 0.76 CCR1 (0.50) CCR1CCR5CCR8KDM4EMETAP1
SCHEMBL5327675 0.76 CBFB (0.59) CCR1CCR5CCR8KDM4EMETAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4702008-A1 ARENE-CHLORINATION USING CHLORINATED WASTE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2026-03-04 EP disclosed
WO-2024223834-A1 ARENE-CHLORINATION USING CHLORINATED WASTE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2024-10-31 WO disclosed
EP-4455127-A1 ARENE-CHLORINATION USING CHLORINATED WASTE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2024-10-30 EP disclosed
WO-2007123910-A2 COPPER-MEDIATED FUNCTIONALIZATION OF ARYL C-H BONDS, AND COMPOUNDS RELATED THERETO BRANDEIS UNIVERSITY (US) 2007-11-01 WO disclosed
WO-2007123910-A2 COPPER-MEDIATED FUNCTIONALIZATION OF ARYL C-H BONDS, AND COMPOUNDS RELATED THERETO BRANDEIS UNIVERSITY (US) 2007-11-01 WO disclosed