Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11001196 | 0.98 | OPRK1 (0.52) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL28340992 | 0.91 | MAPK10 (0.58) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL27601351 | 0.84 | MAPK10 (0.52) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL5348300 | 0.80 | NOS3 (0.58) | NPY5RMAPK10GABRA1GABRA5GABRA3 | |
| Hydrochloric Acid SCHEMBL11002919 | 0.80 | CHRM1 (0.49) | OPRK1PDE4DCHRM1KCNH2LMNA | |
| SCHEMBL8215360 | 0.78 | MAPK10 (0.62) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL6718309 | 0.76 | MAPK10 (0.45) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| SCHEMBL11065454 | 0.75 | OPRK1 (0.52) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Hydrochloric Acid SCHEMBL6718286 | 0.74 | MAPK10 (0.53) | OPRK1PDE4DNR1I2ADORA3HTR2C | |
| Hydrochloric Acid SCHEMBL7402058 | 0.73 | SRD5A2 (0.47) | OPRK1PDE4DNR1I2ADORA3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238685-B2 | Benzo-fused heterocycles as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-07-03 | — | — | US | disclosed |
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | ACTELION PHARMACEUTICALS LTD. | 2005-06-09 | — | — | US | disclosed |
| WO-2003013545-A1 | NOVEL BENZO-FUSED HETEROCYCLES AS ENDOTHELIN ANTAGONISITS | ACTELION PHARMACEUTICALS LTD (CH) | 2003-02-20 | — | — | WO | disclosed |
| US-4549988-A | ANTICONVULSANTS, ANTIDEPRESSANTS, MUSCLE RELAXANTS, CHEMICAL INTERMEDIATES | HOFFMANN-LA ROCHE INC. (US) | 1985-10-29 | — | — | US | disclosed |
| EP-0041627-B1 | 3H-2-BENZAZEPINES, INTERMEDIATES, PROCESSES FOR PREPARING THEM AND COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-08-08 | — | — | EP | disclosed |
| EP-0041627-A2 | 3H-2-benzazepines, intermediates, processes for preparing them and compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | EDNRA, EDNRB, ECE1 | OPRK1 222/4885PDE4D 924/4885NR1I2 355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.