Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15765746 | 0.79 | ALOX5 (0.42) | ALOX5L3MBTL1RAB9AMAPTALDH1A1 | |
| SCHEMBL5168943 | 0.77 | ALOX5 (0.41) | ALOX5RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL4348669 | 0.75 | ALOX5 (0.46) | ALOX5L3MBTL1RAB9AMAPTALDH1A1 | |
| SCHEMBL5846668 | 0.75 | RAB9A (0.41) | ALOX5RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL5846678 | 0.75 | RAB9A (0.41) | ALOX5RAB9AMAPTALDH1A1HPGD | |
| SCHEMBL1144378 | 0.73 | RAB9A (0.40) | ALOX5L3MBTL1RAB9AALDH1A1NPC1 | |
| SCHEMBL9782245 | 0.73 | CES2 (0.40) | ALOX5L3MBTL1RAB9AMAPTALDH1A1 | |
| SCHEMBL4444118 | 0.72 | ALOX5 (0.42) | ALOX5L3MBTL1RAB9AMAPTALDH1A1 | |
| SCHEMBL5263944 | 0.72 | ALOX5 (0.49) | ALOX5GAALMNA | |
| SCHEMBL4640223 | 0.72 | ALOX5 (0.42) | ALOX5RAB9AALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |