Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 17/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 17/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 12/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 12/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 12/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557123 | 0.86 | ADORA1 (0.45) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL4049327 | 0.84 | SLC6A3 (0.60) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL17474564 | 0.82 | CHRM5 (0.59) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL14919952 | 0.81 | CHRM5 (0.56) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL3003772 | 0.75 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL5729554 | 0.73 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL20475211 | 0.72 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL25427702 | 0.71 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL5731017 | 0.71 | CHRM5 (0.48) | CHRM5CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL3197591 | 0.71 | SLC6A3 (0.55) | CHRM5CHRM1CHRM2CHRM4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |