Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5729554 | 0.89 | CHRM5 (0.48) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL25427702 | 0.86 | CHRM5 (0.48) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5731017 | 0.86 | CHRM5 (0.48) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL14920289 | 0.86 | CHRM5 (0.50) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL534910 | 0.86 | CHRM5 (0.50) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL3197591 | 0.86 | SLC6A3 (0.55) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2243902 | 0.85 | ADORA1 (0.46) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18618579 | 0.85 | ESR2 (0.50) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2240101 | 0.84 | CHRM5 (0.61) | ADORA1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL2242238 | 0.84 | CHRM5 (0.53) | ADORA1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | ADORA1 2342/4885CHRM2 4748/4885CHRM4 4765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.