Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.62 |
| ▸ | HTR3A | P46098 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601854 | 0.85 | HTR4 (0.66) | HTR4DRD2DRD4DRD3HTR3A | |
| SCHEMBL257186 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL25557719 | 0.85 | HTR4 (0.68) | HTR4KCNH2 | |
| SCHEMBL255932 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL15854567 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL165828 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL15063225 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL15063215 | 0.85 | HTR3A (0.59) | HTR4CYP2D6CYP2C9DRD2DRD4 | |
| SCHEMBL15651948 | 0.84 | HTR4 (0.78) | HTR4CYP1A2CYP3A4ADRA2ACYP2D6 | |
| SCHEMBL15650737 | 0.83 | HTR4 (0.83) | HTR4CYP1A2CYP3A4ADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094989-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | SERODUS AS (NO) | 2012-04-19 | — | — | US | disclosed |
| EP-2414331-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | Serodus AS (NO) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010112865-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | SERODUS AS (NO) | 2010-10-07 | — | — | WO | disclosed |
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094989-A1 | 5-HT RECEPTOR MODULATING COMPOUNDS | HTR5A, HTR1A, HTR2A | HTR4 9/4885CYP1A2 831/4885CYP3A4 1244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.