Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363181 | 0.81 | CRHR1 (0.54) | CRHR1ADORA3KDM4EGAAMAPT | |
| SCHEMBL5351558 | 0.80 | CRHR1 (0.60) | CRHR1ADORA3KDM4EGAAMAPT | |
| SCHEMBL6678654 | 0.74 | CYP1A1 (0.58) | CRHR1ADORA3KDM4EGAAMAPT | |
| SCHEMBL5357814 | 0.72 | ADORA3 (0.49) | CRHR1ADORA3KDM4EMAPTALDH1A1 | |
| SCHEMBL19490331 | 0.72 | ADORA3 (0.60) | ADORA3KDM4EMAPTALDH1A1POLB | |
| SCHEMBL7488832 | 0.71 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5363188 | 0.71 | CRHR1 (0.61) | CRHR1ADORA3MAPTHSD17B10CYP1A1 | |
| SCHEMBL9917147 | 0.70 | NPC1 (0.57) | CRHR1ADORA3KDM4EGAAMAPT | |
| SCHEMBL10486300 | 0.70 | NPC1 (0.71) | CRHR1ADORA3KDM4EGAAMAPT | |
| SCHEMBL8378539 | 0.70 | NPC1 (0.66) | CRHR1ADORA3KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169790-B2 | 5-substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION (US) | 2007-01-30 | — | — | US | disclosed |
| US-20050234051-A1 | 5-Substituted 2-aryl-4 pyrimidinones | NEUROGEN CORPORATION (US) | 2005-10-20 | — | — | US | disclosed |
| US-6943173-B2 | 5-substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION (US) | 2005-09-13 | — | — | US | disclosed |
| EP-1301490-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2003-04-16 | — | — | EP | disclosed |
| US-20020052387-A1 | 5-Substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION | 2002-05-02 | — | — | US | disclosed |
| WO-2002006242-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052387-A1 | 5-Substituted 2-aryl-4-pyrimidinones | CRHR1, CRHR2, HTR4 | CRHR1 1/4885ADORA3 268/4885KDM4E 2163/4885 |
| US-20050234051-A1 | 5-Substituted 2-aryl-4 pyrimidinones | CRHR1, CRHR2, HTR4 | CRHR1 1/4885ADORA3 242/4885KDM4E 2187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.