Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353273 | 0.82 | CRHR1 (0.54) | CRHR1ALDH1A1HTTGAAMAPK1 | |
| SCHEMBL5351554 | 0.80 | CRHR1 (0.55) | CRHR1ALDH1A1GAANPC1ADORA3 | |
| SCHEMBL6678654 | 0.79 | CYP1A1 (0.58) | CRHR1ALDH1A1HTTGAAMAPK1 | |
| SCHEMBL10486300 | 0.79 | NPC1 (0.71) | CRHR1ALDH1A1HTTGAAMAPK1 | |
| SCHEMBL5363181 | 0.76 | CRHR1 (0.54) | CRHR1ALDH1A1GAAADORA3KDM4E | |
| SCHEMBL5363188 | 0.76 | CRHR1 (0.61) | CRHR1ADORA3CYP1A1CYP1B1CYP3A4 | |
| SCHEMBL7488832 | 0.76 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL7537463 | 0.73 | CRHR1 (0.57) | CRHR1ALDH1A1CYP3A4KDM4EMEN1 | |
| SCHEMBL15698789 | 0.73 | ALDH1A1 (0.54) | CRHR1ALDH1A1HTTGAAMAPK1 | |
| SCHEMBL8378539 | 0.72 | NPC1 (0.66) | CRHR1ALDH1A1HTTNPC1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169790-B2 | 5-substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION (US) | 2007-01-30 | — | — | US | disclosed |
| US-20050234051-A1 | 5-Substituted 2-aryl-4 pyrimidinones | NEUROGEN CORPORATION (US) | 2005-10-20 | — | — | US | disclosed |
| US-6943173-B2 | 5-substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION (US) | 2005-09-13 | — | — | US | disclosed |
| EP-1301490-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2003-04-16 | — | — | EP | disclosed |
| US-20020052387-A1 | 5-Substituted 2-aryl-4-pyrimidinones | NEUROGEN CORPORATION | 2002-05-02 | — | — | US | disclosed |
| WO-2002006242-A2 | 5-SUBSTITUTED 2-ARYL-4-PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2002-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052387-A1 | 5-Substituted 2-aryl-4-pyrimidinones | CRHR1, CRHR2, HTR4 | CRHR1 1/4885ALDH1A1 1083/4885HTT 610/4885 |
| US-20050234051-A1 | 5-Substituted 2-aryl-4 pyrimidinones | CRHR1, CRHR2, HTR4 | CRHR1 1/4885ALDH1A1 1148/4885HTT 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.