Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.43 |
| ▸ | HTR2B | P41595 | 7/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3024089 | 0.82 | HTR2C (0.62) | NOTUMHDAC1HDAC6HTR2AHTR2C | |
| SCHEMBL905724 | 0.82 | HTR2C (0.62) | NOTUMHDAC1HDAC6HTR2AHTR2C | |
| SCHEMBL5357052 | 0.80 | NPY5R (0.46) | NOTUMHDAC1HDAC6HTR2AHTR2C | |
| SCHEMBL5357429 | 0.78 | CTSL (0.48) | NOTUMHDAC1HDAC6HTR2AHTR2C | |
| SCHEMBL5118232 | 0.77 | NOTUM (0.54) | NOTUMHDAC1HDAC6CHRM2CHRM3 | |
| SCHEMBL3012389 | 0.76 | CTSS (0.48) | CTSSCTSLCTSK | |
| SCHEMBL27667528 | 0.76 | CTSS (0.48) | CTSSCTSLCTSK | |
| SCHEMBL3014379 | 0.74 | NOTUM (0.46) | NOTUMHDAC1HDAC6HTR2AHTR2C | |
| SCHEMBL24823574 | 0.73 | NOTUM (0.49) | NOTUMHDAC1HDAC6HTR2CHTR2B | |
| SCHEMBL12060492 | 0.73 | NOTUM (0.53) | NOTUMHDAC1HDAC6HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307095-B2 | Osteoporosis; antiarthritic agents; antidiabetic agents; antiinflammatory agents; Alzheimer's disease; shock; central nervous stsrem disorders; anticancer agents; multiple sclerosis, (S)-2-(Benzooxazol-2-ylamino)-3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-propionamide | IRM LLC (BM) | 2007-12-11 | — | — | US | claimed |
| US-20070123523-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-05-31 | — | — | US | claimed |
| US-7173051-B2 | Inhibitors of cathepsin S | IRM, LLC (BM) | 2007-02-06 | — | — | US | claimed |
| US-20050049244-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2005-03-03 | — | — | US | claimed |
| WO-2004112709-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-12-29 | — | — | WO | claimed |
| US-7507755-B2 | Inhibitors of cathepsin s | IRM LLC (BM) | 2009-03-24 | — | — | US | disclosed |
| US-7507755-B2 | Inhibitors of cathepsin s | IRM LLC (BM) | 2009-03-24 | — | — | US | disclosed |
| US-7307095-B2 | Osteoporosis; antiarthritic agents; antidiabetic agents; antiinflammatory agents; Alzheimer's disease; shock; central nervous stsrem disorders; anticancer agents; multiple sclerosis, (S)-2-(Benzooxazol-2-ylamino)-3-cyclohexyl-N-[2-(5-fluoro-2,3-dihydro-indol-1-yl)-ethyl]-propionamide | IRM LLC (BM) | 2007-12-11 | — | — | US | disclosed |
| US-20070259873-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-11-08 | — | — | US | disclosed |
| US-20070259873-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-11-08 | — | — | US | disclosed |
| US-7256207-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2007-08-14 | — | — | US | disclosed |
| US-7256207-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2007-08-14 | — | — | US | disclosed |
| US-20070123523-A1 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-05-31 | — | — | US | disclosed |
| US-7173051-B2 | Inhibitors of cathepsin S | IRM, LLC (BM) | 2007-02-06 | — | — | US | disclosed |
| US-20050049244-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2005-03-03 | — | — | US | disclosed |
| WO-2005018568-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-03-03 | — | — | WO | disclosed |
| WO-2004112709-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050049244-A1 | Inhibitors of cathepsin S | CTSS, CTSB, CTSZ | NOTUM 796/4885HDAC1 346/4885HDAC6 189/4885 |
| US-20070259873-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | NOTUM 796/4885HDAC1 346/4885HDAC6 189/4885 |
| US-20070123523-A1 | INHIBITORS OF CATHEPSIN S | CTSS, CTSB, CTSZ | NOTUM 796/4885HDAC1 346/4885HDAC6 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.