Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746535 | 0.91 | SIRT6 (0.54) | MAPTALDH1A1HTTTP53LMNA | |
| Hydrochloric Acid SCHEMBL5364983 | 0.89 | SIRT6 (0.52) | MAPTALDH1A1HTTTP53LMNA | |
| SCHEMBL5357980 | 0.84 | SIRT6 (0.52) | MAPTALDH1A1LMNASMN1; SMN2SIRT6 | |
| SCHEMBL5393424 | 0.80 | MAPT (0.54) | MAPTALDH1A1LMNASMN1; SMN2SIRT6 | |
| SCHEMBL5357616 | 0.73 | SIRT6 (0.65) | MAPTALDH1A1LMNASMN1; SMN2SIRT6 | |
| Hydrochloric Acid SCHEMBL5352144 | 0.72 | SIRT6 (0.63) | MAPTALDH1A1LMNASMN1; SMN2SIRT6 | |
| SCHEMBL5351218 | 0.70 | MAPT (0.47) | MAPTALDH1A1HTTTP53LMNA | |
| Hydrochloric Acid SCHEMBL5349721 | 0.69 | MAPT (0.46) | MAPTALDH1A1HTTTP53LMNA | |
| Hydrochloric Acid SCHEMBL5358867 | 0.68 | MAPT (0.46) | MAPTALDH1A1HTTTP53LMNA | |
| SCHEMBL6748663 | 0.68 | MAPT (0.66) | MAPTALDH1A1LMNASMN1; SMN2SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186277-B2 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL SA (FR) | 2007-03-06 | — | — | US | disclosed |
| US-20040237216-A1 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | L'OREAL S.A. (FR) | 2004-12-02 | — | — | US | disclosed |
| EP-1462091-A1 | Composition for dyeing of keratinic fibers comprising a cationic derivative of p-phenylenediamine substituted by a diazacyclohexane or a diazacyloheptane | L'OREAL (FR) | 2004-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040237216-A1 | Composition for dyeing keratin fibres, comprising a cationic para-phenylenediamine derivative substituted with a diazacyclohexane or diazacycloheptane ring | KRT18, CDC73, DSP | ACHE 1016/4885MAPT 2272/4885ALDH1A1 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.