SCHEMBL535304

SCHEMBL535304

N#Cc1cccnc1-n1[c]cc(Cl)n1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.39
HTR2A P28223 3/20 0.39
KDM4E B2RXH2 4/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
RECQL P46063 1/20 0.39
HTR1A P08908 1/20 0.38
HTR7 P34969 1/20 0.38
HSD11B1 P28845 1/20 0.36
PANK3 Q9H999 1/20 0.34
MALT1 Q9UDY8 1/20 0.34
DRD4 P21917 2/20 0.33
GRM5 P41594 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP11B2 P19099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL535996 0.82 KDM4E (0.39) DRD2HTR2AKDM4EALDH1A1MAPT
SCHEMBL536052 0.80 TRPA1 (0.35) KDM4EMAPTHSD11B1MALT1TDP1
SCHEMBL536210 0.79 TRPV1 (0.37) DRD2HTR2AKDM4EALDH1A1MAPT
SCHEMBL535524 0.77 TDP1 (0.31) KDM4EALDH1A1MAPTTDP1
SCHEMBL535573 0.77 CDC25B (0.31) TDP1
SCHEMBL535335 0.77 TRPV1 (0.35) KDM4EALDH1A1MAPTHTR7HSD11B1
SCHEMBL536188 0.77 RPS6KA5 (0.31) KDM4EALDH1A1MAPTTDP1
SCHEMBL535492 0.73 TRPA1 (0.34) DRD2HTR2AKDM4EALDH1A1MAPT
SCHEMBL535494 0.73 MALT1 (0.35) MALT1GRM5
SCHEMBL535912 0.73 EPHX2 (0.44) KDM4EMAPTHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8247431-B2 Heterocyclic hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-21 US disclosed
EP-2144898-B1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2012-02-08 EP disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-22 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC1, UQCRC2, Q6ZSR9 DRD2 611/4885HTR2A 702/4885KDM4E 2026/4885
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 DRD2 556/4885HTR2A 903/4885KDM4E 1084/4885
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC2, UQCRC1, UQCRB DRD2 758/4885HTR2A 612/4885KDM4E 2615/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT DRD2 2975/4885HTR2A 1804/4885KDM4E 2028/4885
US-20100137362-A1 HETEROCYCLIC HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, CAT, DNPH1 DRD2 2999/4885HTR2A 2652/4885KDM4E 2297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.