Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL796231 | 0.82 | CHEK1 (0.58) | CHEK1 | |
| SCHEMBL5362675 | 0.82 | ADORA3 (0.43) | CHEK1NOTUM | |
| SCHEMBL560634 | 0.78 | MAPT (0.54) | CHEK1DAO | |
| SCHEMBL5479035 | 0.72 | CHEK1 (0.68) | CHEK1 | |
| SCHEMBL18544256 | 0.71 | PARP1 (0.38) | DAOPARP1 | |
| SCHEMBL5732439 | 0.69 | PDE2A (0.38) | GRM2 | |
| SCHEMBL19231294 | 0.67 | CYP11B1 (0.44) | PARP1 | |
| SCHEMBL5349697 | 0.65 | HRH4 (0.38) | — | |
| SCHEMBL5357419 | 0.65 | ADORA1 (0.44) | — | |
| SCHEMBL8910786 | 0.65 | DAO (0.49) | GRM2DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |