Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355017 | 0.82 | CHEK1 (0.40) | CHEK1NOTUM | |
| SCHEMBL796231 | 0.82 | CHEK1 (0.58) | CHEK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL560634 | 0.78 | MAPT (0.54) | ADORA3ADORA1CHEK1 | |
| SCHEMBL7352385 | 0.73 | CUL4A (0.48) | ADORA1AHR | |
| SCHEMBL30978979 | 0.71 | KMO (0.40) | NOTUMTLR8 | |
| SCHEMBL5350608 | 0.70 | HPGD (0.44) | CHEK1 | |
| SCHEMBL5468928 | 0.70 | CHEK1 (0.68) | CHEK1 | |
| SCHEMBL10885012 | 0.68 | PRKDC (0.51) | ADORA3ADORA1PIK3CBPRKDCATM | |
| SCHEMBL31612377 | 0.67 | ADORA3 (0.41) | ADORA3ADORA1AHRPIK3CBPRKDC | |
| SCHEMBL30231077 | 0.67 | HPGD (0.45) | ADORA3ADORA1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |