Sugi Predict

Sugi Predict / Compounds / SCHEMBL535568

SCHEMBL535568

SCHEMBL535568

COC(=O)c1ccncc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 1.00
▸ KDM4E B2RXH2 6/20 1.00
▸ GAA P10253 4/20 1.00
▸ GLA P06280 3/20 1.00
▸ MAPT P10636 3/20 0.61
▸ L3MBTL1 Q9Y468 2/20 0.61
▸ KMT2A Q03164 2/20 0.61
▸ KDM4C Q9H3R0 2/20 0.61
▸ MEN1 O00255 1/20 0.61
▸ KDM6B O15054 1/20 0.61
▸ KDM4A O75164 1/20 0.61
▸ THRB P10828 1/20 0.61
▸ KDM4D Q6B0I6 1/20 0.61
▸ TDP1 Q9NUW8 1/20 0.61
▸ HSD17B10 Q99714 4/20 0.56
▸ CFTR P13569 3/20 0.56
▸ HPGD P15428 3/20 0.51
▸ CASP1 P29466 2/20 0.51
▸ CASP7 P55210 2/20 0.51
▸ ATM Q13315 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29464551 1.00 ALDH1A1 (1.00) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL30419031 0.85 ALDH1A1 (0.74) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL1062129 0.85 ALDH1A1 (0.74) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL68952 0.82 KDM4E (0.70) ALDH1A1KDM4EGAAGLAL3MBTL1
SCHEMBL29416299 0.82 KDM4E (0.70) ALDH1A1KDM4EGAAGLAL3MBTL1
SCHEMBL5768957 0.81 ALDH1A1 (0.69) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL29790003 0.81 ALDH1A1 (0.68) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL1841640 0.81 ALDH1A1 (0.68) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL31487718 0.81 ALDH1A1 (0.68) ALDH1A1KDM4EGAAGLAMAPT
SCHEMBL3890104 0.80 ALDH1A1 (0.67) ALDH1A1KDM4EGAAGLAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 291 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387881-B Synthesis method of 3-aminoisonicotinic acid methyl ester 安徽大学 2024-05-14 — — CN claimed
CN-114907318-B Isonicotinic acid-pyrazole derivative and preparation method and application thereof 郑州大学 2023-08-11 — — CN claimed
CN-116426219-A Chemical mechanical polishing solution and application thereof 安集微电子科技（上海）股份有限公司 2023-07-14 — — CN claimed
CN-116023430-A 2- (2- (2-benzoylamino) acetamide) benzoic acid derivative and preparation method and application thereof 中国药科大学 2023-04-28 — — CN claimed
CN-114686112-A Chemical mechanical polishing solution and use method thereof 安集微电子科技（上海）股份有限公司 2022-07-01 — — CN claimed
CN-113387881-A Synthetic method of 3-amino methyl isonicotinate 安徽大学 2021-09-14 — — CN claimed
CN-111100068-A Method for quickly and efficiently synthesizing 3-amino methyl isonicotinate 苏州诚和医药化学有限公司 2020-05-05 — — CN claimed
CN-111018775-A High-yield synthesis method of 3-amino methyl isonicotinate 苏州诚和医药化学有限公司 2020-04-17 — — CN claimed
US-12637428-B2 Isoquinoline derivatives as SIK2 inhibitors CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2026-05-26 — — US disclosed
US-20260125346-A1 Isoquinolinone Derivatives and 4H-Quinolizinone Derivatives and Pharmaceutical Compositions Thereof for the Treatment of Disease BEONE MEDICINES I GMBH (CH) 2026-05-07 — — US disclosed
EP-4709711-A1 ISOQUINOLINONE DERIVATIVES AND 4H-QUINOLIZINONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASE Beone Medicines I GmbH (CH) 2026-03-18 — — EP disclosed
US-20250320204-A1 7-AZA BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS RIBOSCIENCE LLC (US) 2025-10-16 — — US disclosed
EP-4615454-A1 SOS1 INHIBITORS Acerand Therapeutics (Hong Kong) Limited (HK) 2025-09-17 — — EP disclosed
US-20250163043-A1 CDK9 INHIBITOR AND USE THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2025-05-22 — — US disclosed
US-5700940-A FOR PRE- OR POSTEMERGENCE SPRAYING OF PLANTS OR SOILS DOWELANCO (US) 1997-12-23 — — US disclosed
US-5614469-A N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides DOWELANCO (US) 1997-03-25 — — US disclosed
US-5571775-A EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES DOWELANCO (US) 1996-11-05 — — US disclosed
EP-0717745-A1 N-PYRIDINYL 1,2,4]TRIAZOLO 1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-06-26 — — EP disclosed
WO-1996001828-A1 N-PYRIDINYL[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-01-25 — — WO disclosed
US-5461161-A Chemical intermediate is 3-amino-2-hal pyridine DOWELANCO (US) 1995-10-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12637428-B2 Isoquinoline derivatives as SIK2 inhibitors SIK2, SIK1, SIK3 ALDH1A1 4757/4885KDM4E 1688/4885GAA 3848/4885
US-20250320204-A1 7-AZA BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS ENPP1, ENPP3, PDE7A ALDH1A1 745/4885KDM4E 1820/4885GAA 188/4885
US-20260125346-A1 Isoquinolinone Derivatives and 4H-Quinolizinone Derivatives and Pharmaceutical Compositions Thereof for the Treatment of Disease NR3C1, NR3C2, PIK3R4 ALDH1A1 1598/4885KDM4E 3237/4885GAA 1003/4885
US-20250163043-A1 CDK9 INHIBITOR AND USE THEREOF CDK9, CDK19, CDKL1 ALDH1A1 2791/4885KDM4E 510/4885GAA 1906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.