SCHEMBL5356019

SCHEMBL5356019

CC(C)(C)[Si](C)(C)Oc1ccc(C2CCC(NS(=O)(=O)c3ccc4ccccc4c3)CC2)c(O[Si](C)(C)C(C)(C)C)c1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.43
ALDH1A1 P00352 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
DRD2 P14416 7/20 0.40
ADRA1D P25100 7/20 0.40
ADRA1A P35348 7/20 0.40
ADRA1B P35368 7/20 0.40
HTR6 P50406 1/20 0.39
PARG Q86W56 1/20 0.38
DPP4 P27487 1/20 0.38
DPP7 Q9UHL4 1/20 0.38
BRD4 O60885 1/20 0.38
BRD2 P25440 1/20 0.38
BRD3 Q15059 1/20 0.38
POLB P06746 1/20 0.38
ACACB O00763 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5356013 1.00 KMT2A (0.43) KMT2AALDH1A1SMN1; SMN2L3MBTL1DRD2
SCHEMBL5363019 0.90 HTR1A (0.42) ALDH1A1DRD2ADRA1DADRA1AADRA1B
SCHEMBL5356429 0.90 HTR1A (0.42) ALDH1A1DRD2ADRA1DADRA1AADRA1B
SCHEMBL5356423 0.90 HTR1A (0.42) ALDH1A1DRD2ADRA1DADRA1AADRA1B
SCHEMBL5359450 0.87 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2L3MBTL1DRD2BRD4
SCHEMBL5360942 0.87 POLB (0.40) KMT2AALDH1A1SMN1; SMN2DRD2ADRA1D
SCHEMBL5363070 0.87 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2L3MBTL1DRD2BRD4
SCHEMBL5446988 0.87 POLB (0.42) KMT2ASMN1; SMN2L3MBTL1DRD2ADRA1D
SCHEMBL5446985 0.87 POLB (0.42) KMT2ASMN1; SMN2L3MBTL1DRD2ADRA1D
SCHEMBL5359455 0.87 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2L3MBTL1DRD2BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7282592-B2 Resorcinol derivatives WARNER-LAMBERT COMPANY (US) 2007-10-16 US disclosed
US-20070122367-A1 RESORCINOL DERIVATIVES PFIZER INC. (US) 2007-05-31 US disclosed
US-7173052-B2 Resorcinol derivatives PFIZER INC. (US) 2007-02-06 US disclosed
US-20050282899-A1 Resorcinol for lightening skin removing color BRADLEY STUART E 2005-12-22 US disclosed
US-6852747-B2 Resorcinol derivatives PFIZER INC. (US) 2005-02-08 US disclosed
US-20030180236-A1 Resorcinol derivatives PFIZER PRODUCTS, INC. 2003-09-25 US disclosed
US-6590105-B2 For skin lightening or depigmentation; works by inhibiting tyrosinase in humans; kits WARNER-LAMBERT COMPANY 2003-07-08 US disclosed
US-20020114770-A1 Resorcinol derivatives PFIZER INC. 2002-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070122367-A1 RESORCINOL DERIVATIVES LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885
US-20030180236-A1 Resorcinol derivatives LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885
US-20050282899-A1 Resorcinol for lightening skin removing color RBP4, NQO1, ALDH1A2 KMT2A 771/4885ALDH1A1 164/4885SMN1; SMN2 4683/4885
US-20020114770-A1 Resorcinol derivatives LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.