Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | STAMBP | O95630 | 1/20 | 0.48 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352150 | 0.76 | ALDH1A1 (0.55) | HPGDALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5358234 | 0.75 | LMNA (0.48) | KMT2AMEN1HPGDCYP1A2CYP2C9 | |
| SCHEMBL5364346 | 0.73 | TP53 (0.52) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL5358019 | 0.72 | FGFR1 (0.49) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL30265332 | 0.72 | QPCT (0.64) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL31744961 | 0.71 | FGFR1 (0.40) | KMT2AMEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL13210604 | 0.70 | KMT2A (0.72) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL280094 | 0.69 | KMT2A (0.71) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL13450229 | 0.69 | KMT2A (0.71) | KMT2AMEN1HPGDALDH1A1RAB9A | |
| SCHEMBL5422109 | 0.69 | KMT2A (0.71) | KMT2AMEN1HPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |