Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358234 | 0.83 | LMNA (0.48) | TP53MEN1KMT2ALMNAPOLB | |
| SCHEMBL5358019 | 0.78 | FGFR1 (0.49) | RAB9ANPC1SMN1; SMN2GAAKDM4E | |
| SCHEMBL5352150 | 0.78 | ALDH1A1 (0.55) | ALDH1A1POLBHPGD | |
| SCHEMBL31744961 | 0.75 | FGFR1 (0.40) | SMN1; SMN2KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL5355346 | 0.74 | LMNA (0.55) | TP53SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5356306 | 0.73 | KMT2A (0.54) | TP53RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL14027512 | 0.69 | ADORA3 (0.76) | RAB9ANPC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19994540 | 0.69 | L3MBTL1 (0.78) | RAB9ASMN1; SMN2HDAC6HDAC1KDM4E | |
| SCHEMBL6842122 | 0.67 | HDAC2 (0.80) | TP53RAB9ANPC1SMN1; SMN2HDAC2 | |
| SCHEMBL9011235 | 0.67 | RAB9A (0.73) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |