Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | CTSB | P07858 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | JMJD7 | P0C870 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2472026 | 0.85 | CTSV (0.41) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL2553633 | 0.83 | CYP11B1 (0.43) | MAPTLMNAMAPK14CTSBJMJD7 | |
| SCHEMBL2473217 | 0.83 | MAPT (0.43) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL29662541 | 0.80 | MAPT (0.50) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL535504 | 0.80 | MAPT (0.50) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL2475270 | 0.79 | ALDH1A1 (0.42) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL29186391 | 0.79 | MAPT (0.47) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL2473665 | 0.79 | ALDH1A1 (0.48) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2891270 | 0.77 | MAPT (0.41) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL2562936 | 0.77 | MAPK14 (0.49) | MAPTLMNAALDH1A1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414347-A1 | P38MAP KINASE INHIBITOR | Respivert Limited (GB) | 2012-02-08 | — | — | EP | disclosed |
| EP-2370429-A1 | P38 MAP KINASE INHIBITORS | Respivert Limited (GB) | 2011-10-05 | — | — | EP | disclosed |