Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 5/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5357681 | 0.75 | CASP1 (0.41) | CYP11B2ARGRIA1CACNG8CASP1 | |
| SCHEMBL6468361 | 0.74 | CYP2A6 (0.42) | CYP11B2ARCDK4CDK2 | |
| SCHEMBL3076212 | 0.73 | IKBKB (0.49) | CYP11B2TRPV4NSD2ARCYP11B1 | |
| SCHEMBL5365964 | 0.73 | CYP11B2 (0.47) | CYP11B2TRPV4ARCYP11B1MAOA | |
| SCHEMBL24186806 | 0.71 | CYP11B2 (0.44) | CYP11B2TRPV4NSD2ARCYP11B1 | |
| SCHEMBL5711187 | 0.70 | CYP11B2 (0.54) | CYP11B2TRPV4ARCYP11B1GRIA1 | |
| SCHEMBL6890109 | 0.68 | AR (0.53) | NSD2AR | |
| SCHEMBL18666733 | 0.67 | CYP11B2 (0.50) | CYP11B2TRPV4NSD2ARCYP11B1 | |
| SCHEMBL410587 | 0.66 | TRPV4 (0.57) | CYP11B2TRPV4ARMAOAMAOB | |
| SCHEMBL11560121 | 0.66 | CYP11B2 (0.49) | CYP11B2TRPV4NSD2ARCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007145349-A2 | SUBSTITUTED PYRROLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-12-21 | — | — | WO | disclosed |