SCHEMBL535842

SCHEMBL535842

[c]1ccnn1-c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.34
KDM4E B2RXH2 2/20 0.33
HPGD P15428 1/20 0.33
GAA P10253 2/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
CYP19A1 P11511 2/20 0.31
NOTUM Q6P988 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16446576 0.82 CHKA (0.37) LMNAMAPT
SCHEMBL9804027 0.78 NOTUM (0.42) LMNAMAPTCYP19A1NOTUM
SCHEMBL1970934 0.77 NOTUM (0.45) CYP3A4KDM4EHPGDGAALMNA
SCHEMBL16446130 0.74 CYP1A2 (0.44) POLBGAALMNAMAPT
SCHEMBL535441 0.72 SMN1; SMN2 (0.40) POLBKDM4EGAALMNA
SCHEMBL535848 0.71 BCHE (0.38) KDM4ELMNAMAPTNOTUM
SCHEMBL16446572 0.70 L3MBTL1 (0.40) POLBKDM4EGAAMAPT
SCHEMBL16446609 0.67 MGLL (0.42) POLBKDM4EHPGDGAALMNA
SCHEMBL1916262 0.67 KCNH2 (0.31) LMNA
SCHEMBL535613 0.65 MALT1 (0.36) KDM4ELMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230416205-A1 COMPOUNDS, COMPOSITIONS, AND METHODS TENVIE THERAPEUTICS, INC. 2023-12-28 US claimed
EP-4247376-A1 COMPOUNDS, COMPOSITIONS, AND METHODS Denali Therapeutics Inc. (US) 2023-09-27 EP claimed
CN-116507608-A Compounds, compositions, and methods 戴纳立制药公司 2023-07-28 CN claimed
CN-114933758-A Quantum dot thin film material with gas-sensitive performance and application thereof 江苏烨湫传感科技有限公司 2022-08-23 CN claimed
CN-114540024-A Perovskite quantum dot material with gas-sensitive property and application thereof 江苏烨湫传感科技有限公司 2022-05-27 CN claimed
WO-2022109268-A1 COMPOUNDS, COMPOSITIONS, AND METHODS DENALI THERAPEUTICS INC. (US) 2022-05-27 WO claimed
US-RE48841-E1 Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators JANSSEN PHARMACEUTICA NV (BE) 2021-12-07 US claimed
EP-3089980-B1 SERINE/THREONINE KINASE INHIBITORS ARRAY BIOPHARMA INC (US) 2018-01-31 EP claimed
US-9670208-B2 Serine/threonine kinase inhibitors ARRAY BIOPHARMA INC. (US) 2017-06-06 US claimed
EP-3089980-A1 SERINE/THREONINE KINASE INHIBITORS Array Biopharma, Inc. (US) 2016-11-09 EP claimed
EP-0796857-A1 4-thia-1-azabicyclo(3.2.0)heptane-3-imino-2-isopropylidene-7-oxo analogons of beta-lactams, processes for their preparation and the use thereof PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) 1997-09-24 EP claimed
EP-0659177-A1 4-OXO-AZETIDINE-2-SULPHONIC ACID AMIDES AND THEIR SALTS, PROCESS FOR THEIR PRODUCTION AND THEIR USE PLIVA Handels GmbH (DE) 1995-06-28 EP claimed
WO-1994005632-A1 4-OXO-AZETIDINE-2-SULPHONIC ACID AMIDES AND THEIR SALTS, PROCESS FOR THEIR PRODUCTION AND THEIR USE PLIVA HANDELS GMBH (DE) 1994-03-17 WO claimed
US-5185027-A Salicylaldehyde derivatives and salicyclic acid derivatives and their sulfur analogs, and their use as herbicides and bioregulators BASF AKTIENGESELLSCHAFT (DE) 1993-02-09 US claimed
US-5085686-A Plant growth regulator BASF AKTIENGESELLSCHAFT (DE) 1992-02-04 US claimed
US-5026848-A Antirhinovirus agents SYNPHAR LABORATORIES INCORPORATED (CA) 1991-06-25 US claimed
EP-0335636-A1 Antiviral compounds SYNPHAR LABORATORIES INC. (CA) 1989-10-04 EP claimed
US-4853404-A DIURETIS, SALURETICS, URICOSURETICS TANABE SEIYAKU CO., LTD. (JP) 1989-08-01 US claimed
EP-0268800-A1 Phenoxyacetic acid derivatives and processes for preparing the same Tanabe Seiyaku Co., Ltd. (JP) 1988-06-01 EP claimed
CN-87106895-A Phenoxyacetic acid derivatives and process for producing the same 1988-04-20 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230416205-A1 COMPOUNDS, COMPOSITIONS, AND METHODS NLRP3, NLRP1, NOD1 POLB 3627/4885CYP3A4 3054/4885KDM4E 3822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.