Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | PTH1R | Q03431 | 5/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CCKBR | P32239 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321928 | 0.88 | ALDH1A1 (0.35) | PTH1RCREBBPCHRM1NR1I2KDM4B | |
| SCHEMBL5352183 | 0.85 | PTH1R (0.36) | BCHECES1PTH1RCHRM1NR1I2 | |
| SCHEMBL5355386 | 0.83 | ALDH1A1 (0.36) | PTH1RCREBBPCHRM1NR1I2KDM4B | |
| SCHEMBL5362739 | 0.82 | PTH1R (0.35) | PTH1RCREBBPCHRM1NR1I2KDM4B | |
| SCHEMBL5323349 | 0.81 | ALDH1A1 (0.34) | PTH1RALDH1A1 | |
| SCHEMBL5329713 | 0.80 | PTH1R (0.45) | PTH1RCHRM1NR1I2KDM4BTBXA2R | |
| SCHEMBL5326023 | 0.80 | PTH1R (0.37) | PTH1RCCKBR | |
| SCHEMBL5355360 | 0.77 | BRD4 (0.36) | PTH1RCREBBPALDH1A1CCKBR | |
| SCHEMBL5355357 | 0.77 | BRD4 (0.36) | PTH1RCREBBPALDH1A1CCKBR | |
| SCHEMBL5355040 | 0.76 | PTH1R (0.39) | PTH1RALDH1A1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |