SCHEMBL5360993

SCHEMBL5360993

O=S(=O)(NC1CCC(c2ccc(O)cc2O)CC1)c1ccc2ccccc2c1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.51
ALDH1A1 P00352 2/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
STS P08842 1/20 0.47
MEN1 O00255 1/20 0.46
DPP4 P27487 1/20 0.46
DPP7 Q9UHL4 1/20 0.46
PARG Q86W56 1/20 0.45
KAT6A Q92794 3/20 0.44
F10 P00742 3/20 0.44
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
DRD2 P14416 2/20 0.41
HTR2A P28223 2/20 0.41
HTR7 P34969 2/20 0.41
HTR6 P50406 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5360989 1.00 KMT2A (0.51) KMT2AALDH1A1SMN1; SMN2STSMEN1
SCHEMBL5374721 0.87 ALDH1A1 (0.48) KMT2AALDH1A1SMN1; SMN2STSPARG
SCHEMBL5374245 0.87 ALDH1A1 (0.48) KMT2AALDH1A1SMN1; SMN2STSPARG
SCHEMBL5374241 0.87 ALDH1A1 (0.48) KMT2AALDH1A1SMN1; SMN2STSPARG
SCHEMBL3683615 0.82 KMT2A (0.69) KMT2AALDH1A1SMN1; SMN2DPP4DPP7
SCHEMBL5363218 0.82 KDM4E (0.44) KMT2AALDH1A1SMN1; SMN2MEN1DPP4
SCHEMBL5359940 0.82 ALDH1A1 (0.55) KMT2AALDH1A1SMN1; SMN2STSMEN1
SCHEMBL5359944 0.82 ALDH1A1 (0.55) KMT2AALDH1A1SMN1; SMN2STSMEN1
SCHEMBL5366825 0.82 STS (0.45) KMT2AALDH1A1SMN1; SMN2STSLMNA
SCHEMBL6599031 0.82 KMT2A (0.48) KMT2AALDH1A1SMN1; SMN2STSLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6852747-B2 Resorcinol derivatives PFIZER INC. (US) 2005-02-08 US claimed
EP-1317425-B1 RESORCINOL DERIVATIVES PFIZER PROD INC (US) 2004-11-03 EP claimed
US-20030180236-A1 Resorcinol derivatives PFIZER PRODUCTS, INC. 2003-09-25 US claimed
US-6590105-B2 For skin lightening or depigmentation; works by inhibiting tyrosinase in humans; kits WARNER-LAMBERT COMPANY 2003-07-08 US claimed
US-20020114770-A1 Resorcinol derivatives PFIZER INC. 2002-08-22 US claimed
US-7282592-B2 Resorcinol derivatives WARNER-LAMBERT COMPANY (US) 2007-10-16 US disclosed
US-20070122367-A1 RESORCINOL DERIVATIVES PFIZER INC. (US) 2007-05-31 US disclosed
US-7173052-B2 Resorcinol derivatives PFIZER INC. (US) 2007-02-06 US disclosed
US-20050282899-A1 Resorcinol for lightening skin removing color BRADLEY STUART E 2005-12-22 US disclosed
US-6852747-B2 Resorcinol derivatives PFIZER INC. (US) 2005-02-08 US disclosed
EP-1317425-B1 RESORCINOL DERIVATIVES PFIZER PROD INC (US) 2004-11-03 EP disclosed
US-20030180236-A1 Resorcinol derivatives PFIZER PRODUCTS, INC. 2003-09-25 US disclosed
US-6590105-B2 For skin lightening or depigmentation; works by inhibiting tyrosinase in humans; kits WARNER-LAMBERT COMPANY 2003-07-08 US disclosed
US-20020114770-A1 Resorcinol derivatives PFIZER INC. 2002-08-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070122367-A1 RESORCINOL DERIVATIVES LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885
US-20030180236-A1 Resorcinol derivatives LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885
US-20050282899-A1 Resorcinol for lightening skin removing color RBP4, NQO1, ALDH1A2 KMT2A 771/4885ALDH1A1 164/4885SMN1; SMN2 4683/4885
US-20020114770-A1 Resorcinol derivatives LRAT, NQO1, ALDH1A2 KMT2A 2259/4885ALDH1A1 90/4885SMN1; SMN2 4867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.