Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.51 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356998 | 0.85 | OPRL1 (0.57) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL5361785 | 0.76 | OPRM1 (0.58) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL7696524 | 0.75 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL20003975 | 0.74 | SLC6A4 (0.48) | OPRM1OPRD1OPRK1OPRL1TACR1 | |
| SCHEMBL5361644 | 0.73 | SLC6A4 (0.41) | TACR1SLC6A2SLC6A4 | |
| SCHEMBL27982226 | 0.72 | ALDH1A1 (0.44) | MEN1KMT2ATP53CYP1A2CYP3A4 | |
| SCHEMBL16565196 | 0.70 | SLC6A4 (0.52) | OPRM1CHRM1TACR1SLC6A2SLC6A4 | |
| SCHEMBL3444050 | 0.70 | CACNA2D1 (0.42) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL5189804 | 0.69 | CACNA2D1 (0.45) | OPRM1OPRD1OPRK1OPRL1CACNA2D1 | |
| SCHEMBL14359682 | 0.69 | DPP4 (0.52) | CHRM1CHRM2TACR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225331-A1 | 4,4-Disubstituted piperidines, and methods of use thereof | SEPRACOR INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-7217823-B2 | 4,4-Disubstituted piperidines, and methods of use thereof | SEPRACOR INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20040142974-A1 | 4,4-disubstituted piperidines, and methods of use thereof | HOEMANN MICHAEL Z (US) | 2004-07-22 | — | — | US | disclosed |
| US-6656953-B2 | Ligands for receptors such as dopamine, serotonin, or norepinephrine transporters; broad uses claimed, such as pain reliever and antidepressant | SEPRACOR INC. | 2003-12-02 | — | — | US | disclosed |
| US-20020177607-A1 | 4,4-Disubstitued piperidines, and methods of use thereof | SEPRACOR INC. | 2002-11-28 | — | — | US | disclosed |
| WO-2002046156-A2 | 4,4-DISUBSTITUTED PIPERIDINES FOR USE AS DOPAMINE, SEROTONIN AND NOREPINEPHRINE LIGANDS | SEPRACOR, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177607-A1 | 4,4-Disubstitued piperidines, and methods of use thereof | HTR2C, HTR5A, OPRL1 | OPRM1 28/4885OPRD1 16/4885OPRK1 15/4885 |
| US-20070225331-A1 | 4,4-Disubstituted piperidines, and methods of use thereof | HTR5A, HTR2C, OPRL1 | OPRM1 25/4885OPRD1 18/4885OPRK1 15/4885 |
| US-20040142974-A1 | 4,4-disubstituted piperidines, and methods of use thereof | HTR5A, HTR2C, OPRL1 | OPRM1 25/4885OPRD1 18/4885OPRK1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.