Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.58 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356998 | 0.84 | OPRL1 (0.57) | OPRM1OPRD1OPRK1OPRL1CYP2D6 | |
| SCHEMBL7696524 | 0.82 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL5361649 | 0.76 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL5361779 | 0.74 | MEN1 (0.45) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL20804480 | 0.74 | SIGMAR1 (0.59) | OPRM1OPRD1OPRK1OPRL1CHRM1 | |
| SCHEMBL10057690 | 0.72 | CYP2D6 (0.62) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL13939172 | 0.70 | OPRM1 (0.64) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL21964989 | 0.70 | POLB (0.48) | OPRM1OPRL1SLC6A4SLC6A3GRIN2B | |
| SCHEMBL985496 | 0.69 | F10 (0.45) | OPRM1OPRL1SLC6A4SLC6A3GRIN2B | |
| SCHEMBL26358348 | 0.69 | OPRM1 (0.45) | OPRM1OPRD1OPRK1OPRL1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225331-A1 | 4,4-Disubstituted piperidines, and methods of use thereof | SEPRACOR INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-7217823-B2 | 4,4-Disubstituted piperidines, and methods of use thereof | SEPRACOR INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-20040142974-A1 | 4,4-disubstituted piperidines, and methods of use thereof | HOEMANN MICHAEL Z (US) | 2004-07-22 | — | — | US | disclosed |
| US-6656953-B2 | Ligands for receptors such as dopamine, serotonin, or norepinephrine transporters; broad uses claimed, such as pain reliever and antidepressant | SEPRACOR INC. | 2003-12-02 | — | — | US | disclosed |
| US-20020177607-A1 | 4,4-Disubstitued piperidines, and methods of use thereof | SEPRACOR INC. | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177607-A1 | 4,4-Disubstitued piperidines, and methods of use thereof | HTR2C, HTR5A, OPRL1 | OPRM1 28/4885OPRD1 16/4885OPRK1 15/4885 |
| US-20070225331-A1 | 4,4-Disubstituted piperidines, and methods of use thereof | HTR5A, HTR2C, OPRL1 | OPRM1 25/4885OPRD1 18/4885OPRK1 15/4885 |
| US-20040142974-A1 | 4,4-disubstituted piperidines, and methods of use thereof | HTR5A, HTR2C, OPRL1 | OPRM1 25/4885OPRD1 18/4885OPRK1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.