Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3919086 | 0.82 | MAOA (0.52) | GLRA1MAOAMAOBRAB9ALMNA | |
| SCHEMBL146577 | 0.80 | MAOA (0.55) | MAOAMAOBRAB9ALMNAHPGD | |
| SCHEMBL31419968 | 0.80 | GLRA1 (0.62) | GLRA1MAOBRAB9ALMNAHPGD | |
| SCHEMBL27620050 | 0.79 | MAOA (0.52) | GLRA1MAOAMAOBRAB9ALMNA | |
| SCHEMBL16860678 | 0.79 | GLRA1 (0.79) | GLRA1LMNAHPGDSMN1; SMN2MEN1 | |
| SCHEMBL28078446 | 0.79 | GLRA1 (0.60) | GLRA1MAOBLMNAHPGDALDH1A1 | |
| SCHEMBL9261857 | 0.78 | GLRA1 (0.53) | GLRA1MAOAMAOBLMNAHPGD | |
| SCHEMBL6035907 | 0.78 | GLRA1 (0.50) | GLRA1MAOAMAOBL3MBTL1CCNB2 | |
| SCHEMBL28060083 | 0.78 | GLRA1 (0.53) | GLRA1MAOAMAOBLMNAHPGD | |
| SCHEMBL4045055 | 0.78 | MAOA (0.57) | MAOAMAOBRAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-62029570-A | — | — | None | — | — | JP | disclosed |
| CN-105849088-B | Pharmacologically active compounds | 利物浦大学 | 2020-07-03 | — | — | CN | disclosed |
| EP-3421450-B1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | UNIV LIVERPOOL (GB) | 2020-02-05 | — | — | EP | disclosed |
| US-10442814-B2 | Pharmacologically active compounds | UNIVERSITY OF LIVERPOOL (GB) | 2019-10-15 | — | — | US | disclosed |
| US-10442814-B2 | Pharmacologically active compounds | UNIVERSITY OF LIVERPOOL (GB) | 2019-10-15 | — | — | US | disclosed |
| US-20190084993-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2019-03-21 | — | — | US | disclosed |
| US-20190084993-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2019-03-21 | — | — | US | disclosed |
| EP-3421450-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | The University Of Liverpool (GB) | 2019-01-02 | — | — | EP | disclosed |
| EP-3421450-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | The University Of Liverpool (GB) | 2019-01-02 | — | — | EP | disclosed |
| EP-3087055-B1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | UNIV LIVERPOOL (GB) | 2018-08-29 | — | — | EP | disclosed |
| US-20160318947-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2016-11-03 | — | — | US | disclosed |
| US-20160318947-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2016-11-03 | — | — | US | disclosed |
| EP-3087055-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | The University of Liverpool (GB) | 2016-11-02 | — | — | EP | disclosed |
| WO-2015097475-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2015-07-02 | — | — | WO | disclosed |
| WO-2015097475-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2015-07-02 | — | — | WO | disclosed |
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |
| US-6133305-A | PREVENTION AND TREATMENT OF PROTEIN KINASE RELATED DISORDERS SUCH AS CANCER | SUGEN, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| JP-S6229570-A | 3,5-DIISOPROPYLBENZYLIDENE HETEROCYCLIC COMPOUND | KANEGAFUCHI CHEM IND CO LTD | 1987-02-07 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10442814-B2 | Pharmacologically active compounds | GRIN1, OPRL1, OPRK1 | GLRA1 13/4885MAOA 1380/4885MAOB 1392/4885 |
| US-20190084993-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | GRIN1, OPRL1, OPRK1 | GLRA1 13/4885MAOA 1380/4885MAOB 1392/4885 |
| US-20160318947-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS | GRIN1, OPRL1, OPRK1 | GLRA1 13/4885MAOA 1380/4885MAOB 1392/4885 |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | GLRA1 4463/4885MAOA 1231/4885MAOB 867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.