Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TACR2 | P21452 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27620050 | 0.89 | MAOA (0.52) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL11890529 | 0.88 | ALDH1A1 (0.49) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL19923160 | 0.86 | MAOA (0.52) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL21547995 | 0.84 | ALDH1A1 (0.51) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL5363004 | 0.82 | GLRA1 (0.62) | MAOAMAOBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21354412 | 0.82 | RAB9A (0.66) | ALDH1A1SMN1; SMN2KDM4ELMNAGLRA1 | |
| SCHEMBL5119999 | 0.82 | ALDH1A1 (0.54) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL2460248 | 0.82 | TACR2 (0.53) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL584489 | 0.82 | TACR2 (0.62) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 | |
| SCHEMBL29446267 | 0.82 | TACR2 (0.62) | MAOAMAOBALDH1A1SMN1; SMN2TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114846001-B | Benzo condensed ring compound | 南京明德新药研发有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-114846001-A | Benzo-fused ring compounds | 南京明德新药研发有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021135335-A1 | LIVER-TARGETING COMPOUND HAVING THYROID HORMONE RECEPTOR AGONIST CHARACTERISTICS AND PHARMACEUTICAL COMPOSITION THEREOF | 厦门甘宝利生物医药有限公司 | 2021-07-08 | — | — | WO | disclosed |
| WO-2021129827-A1 | BENZO FUSED RING-BASED COMPOUND | 南京明德新药研发有限公司 | 2021-07-01 | — | — | WO | disclosed |
| CN-109641858-B | Crystals and salts of resorcin derivatives and process for producing the same | 正大天晴药业集团股份有限公司 | 2021-06-25 | — | — | CN | disclosed |
| US-10851071-B2 | M-dihydroxybenzene derivative crystal and salt, and manufacturing method thereof | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-12-01 | — | — | US | disclosed |
| US-20190284146-A1 | M-DIHYDROXYBENZENE DERIVATIVE CRYSTAL AND SALT, AND MANUFACTURING METHOD THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-09-19 | — | — | US | disclosed |
| CN-109641858-A | The crystallization of resorcinol analog derivative, salt and preparation method thereof | 正大天晴药业集团股份有限公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-107108591-A | It is used as the resorcinol analog derivative of HSP90 inhibitor | 正大天晴药业集团股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| US-20090176841-A1 | NOVEL 6-5 SYSTEM BICYCLIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 2009-07-09 | — | — | US | disclosed |
| EP-2036887-A1 | NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF | Sanwa Kagaku Kenkyusho Co., Ltd (JP) | 2009-03-18 | — | — | EP | disclosed |
| US-7230031-B2 | Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-06-12 | — | — | US | disclosed |
| US-20050085541-A1 | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-04-21 | — | — | US | disclosed |
| EP-1471049-A1 | NOVEL THYROID HORMONE RECEPTOR LIGAND, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND USE THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085541-A1 | Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof | TSHR, THRA, THRB | MAOA 2245/4885MAOB 2276/4885ALDH1A1 3008/4885 |
| US-20190284146-A1 | M-DIHYDROXYBENZENE DERIVATIVE CRYSTAL AND SALT, AND MANUFACTURING METHOD THEREOF | HSP90AB1, HSP90AA1, HSP90AB2P | MAOA 3223/4885MAOB 884/4885ALDH1A1 1211/4885 |
| US-10851071-B2 | M-dihydroxybenzene derivative crystal and salt, and manufacturing method thereof | HSP90AB1, HSP90AA1, HSP90AB2P | MAOA 3223/4885MAOB 884/4885ALDH1A1 1211/4885 |
| US-20090176841-A1 | NOVEL 6-5 SYSTEM BICYCLIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY | TSHR, TRHR, THRA | MAOA 2522/4885MAOB 2178/4885ALDH1A1 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.