Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | CKS1B | P61024 | 2/20 | 0.42 |
| ▸ | SKP1 | P63208 | 2/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14445210 | 0.95 | PIK3CA (0.49) | PIK3CAGPR119TGFBR1BACE1CKS1B | |
| SCHEMBL5203252 | 0.89 | PIK3CA (0.49) | PIK3CAGPR119TGFBR1BACE1CKS1B | |
| SCHEMBL5203030 | 0.80 | TGFBR1 (0.46) | PIK3CAGPR119TGFBR1BACE1CKS1B | |
| SCHEMBL14395516 | 0.79 | TGFBR1 (0.48) | GPR119TGFBR1STS | |
| SCHEMBL2197307 | 0.78 | HTR2A (0.63) | PIK3CAGPR119BACE1CKS1BSKP1 | |
| SCHEMBL27507705 | 0.78 | HTR6 (0.40) | — | |
| SCHEMBL6588562 | 0.78 | BACE1 (0.46) | GPR119BACE1CKS1BSKP1SKP2 | |
| SCHEMBL4867662 | 0.77 | PIK3CA (0.49) | PIK3CAGPR119TGFBR1BACE1CKS1B | |
| SCHEMBL5202415 | 0.77 | HTR6 (0.52) | PIK3CAGPR119TGFBR1BACE1CKS1B | |
| SCHEMBL14445211 | 0.76 | CKS1B (0.44) | GPR119BACE1CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247651-B2 | 2,7-substituted indoles | ROCHE PALO ALTO LLC (US) | 2007-07-24 | — | — | US | disclosed |
| US-20040063724-A1 | Neurotransmitter 5-hydroxytryptamine-6 (5-HT6) antagonists | ROCHE PALO ALTO LLC | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063724-A1 | Neurotransmitter 5-hydroxytryptamine-6 (5-HT6) antagonists | HTR6, HTR5A, HTR1A | PIK3CA 2555/4885GPR119 292/4885TGFBR1 1879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.