Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.54 |
| ▸ | ESRRA | P11474 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | RARB | P10826 | 2/20 | 0.49 |
| ▸ | RARG | P13631 | 2/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310374 | 0.84 | CA12 (0.65) | HSP90AA1HSP90AB1ESRRANR1H4RARB | |
| SCHEMBL39054 | 0.84 | CA12 (0.63) | ALDH1A1LMNAALOX15HTTHSD17B10 | |
| SCHEMBL1570461 | 0.81 | CA12 (0.47) | ALDH1A1LMNAALOX15HTTHSD17B10 | |
| SCHEMBL11611460 | 0.80 | LMNA (0.50) | ALDH1A1LMNATYRALOX15HTT | |
| SCHEMBL5364276 | 0.80 | CA12 (0.68) | HSP90AA1HSP90AB1ESRRANR1H4RARB | |
| SCHEMBL2609133 | 0.79 | CA12 (0.50) | ALDH1A1LMNAALOX15HTTHSD17B10 | |
| SCHEMBL31587898 | 0.79 | CA12 (0.46) | ALDH1A1LMNAMIFALOX15HTT | |
| SCHEMBL1121892 | 0.79 | ALOX15 (0.51) | NR1H4ALDH1A1LMNAALOX15HTT | |
| SCHEMBL10776576 | 0.79 | ESR1 (0.55) | ALDH1A1LMNAALOX15HTTHSD17B10 | |
| SCHEMBL384263 | 0.78 | RARB (0.71) | HSP90AA1HSP90AB1ESRRANR1H4RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205409-B2 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2007-04-17 | — | — | US | disclosed |
| US-20050131019-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBVIE INC. | 2005-06-16 | — | — | US | disclosed |
| WO-2005023762-A1 | PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131019-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | HSP90AA1 3365/4885HSP90AB1 2858/4885ESRRA 3288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.