Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.58 |
| ▸ | DPP4 | P27487 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.53 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.53 |
| ▸ | FAP | Q12884 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | AKT2 | P31751 | 1/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361667 | 0.89 | OPRK1 (0.57) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL2375481 | 0.89 | OPRK1 (0.71) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL2375476 | 0.89 | OPRK1 (0.71) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL5359350 | 0.86 | DPP4 (0.57) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL5367391 | 0.86 | CHRM1 (0.48) | OPRD1OPRK1POLB | |
| SCHEMBL3133533 | 0.86 | OPRD1 (0.65) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL6161830 | 0.86 | OPRD1 (0.65) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL2375638 | 0.85 | OPRD1 (0.61) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL7364618 | 0.85 | OPRK1 (0.57) | HDAC8OPRD1OPRK1DPP4POLB | |
| SCHEMBL2375634 | 0.85 | OPRD1 (0.61) | HDAC8OPRD1OPRK1DPP4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |