Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.56 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5464736 | 0.88 | HRH3 (0.57) | HRH3AVPR1AOXTRAVPR2 | |
| SCHEMBL1222056 | 0.84 | AVPR1A (0.59) | HRH3AVPR1AOXTRAVPR2SIGMAR1 | |
| SCHEMBL6993813 | 0.84 | AVPR1A (0.59) | HRH3AVPR1AOXTRAVPR2SIGMAR1 | |
| SCHEMBL29990866 | 0.84 | AVPR1A (0.59) | HRH3AVPR1AOXTRAVPR2SIGMAR1 | |
| SCHEMBL30388709 | 0.83 | AVPR1A (0.58) | HRH3AVPR1AOXTRAVPR2SIGMAR1 | |
| SCHEMBL15963499 | 0.82 | AVPR1A (0.56) | HRH3AVPR1AOXTR | |
| SCHEMBL15963111 | 0.81 | AVPR1A (0.62) | HRH3AVPR1AOXTRAVPR2 | |
| SCHEMBL15963517 | 0.80 | AVPR1A (0.53) | HRH3AVPR1AOXTRAVPR2 | |
| SCHEMBL15963488 | 0.80 | AVPR1A (0.55) | HRH3AVPR1AOXTR | |
| SCHEMBL18701840 | 0.80 | AVPR1A (0.58) | HRH3AVPR1AOXTRAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | claimed |
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | INCYTE CORPORATION | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208001-A1 | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same | HSD11B1, HSD17B1, HSD3B1 | HRH3 2984/4885AVPR1A 2125/4885OXTR 4047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.