Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409931 | 0.80 | BRD4 (0.53) | BRD4PTPN11HTTLMNAMAPT | |
| SCHEMBL29004620 | 0.76 | PTPN11 (0.50) | PTPN11GSK3B | |
| SCHEMBL28812751 | 0.67 | KDR (0.40) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27680347 | 0.65 | AXL (0.51) | BRD4GSK3B | |
| SCHEMBL1850782 | 0.64 | BRD4 (0.64) | BRD4PTPN11HTTLMNAMAPT | |
| SCHEMBL147390 | 0.64 | RAB9A (0.36) | LMNAMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4806621 | 0.63 | NPC1 (0.34) | MAPT | |
| SCHEMBL28027612 | 0.63 | TDP1 (0.33) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19250318 | 0.63 | RXRA (0.38) | HTTLMNAMAPTPDE11AKDM4E | |
| SCHEMBL21054111 | 0.63 | CYP2A6 (0.46) | GPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106236-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| EP-1781654-A1 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015123-A1 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |