Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 9/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30955215 | 0.78 | MAPT (0.56) | KMT2AMAPTHPGDMAPK10L3MBTL1 | |
| SCHEMBL9206595 | 0.77 | ALDH1A1 (0.37) | KMT2AMEN1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2836274 | 0.73 | MEN1 (0.46) | KMT2AMEN1METAP2MAPTHPGD | |
| SCHEMBL4974399 | 0.72 | MAPT (0.43) | KMT2AMEN1ADRA2AADRA2CADRA1D | |
| SCHEMBL6320333 | 0.71 | ADRA2C (0.49) | KMT2AMEN1ADRA2BADRA2CMAPT | |
| SCHEMBL183017 | 0.71 | HTT (0.59) | KMT2AMEN1ADRA2AADRA2BADRA2C | |
| SCHEMBL1239469 | 0.71 | — | — | |
| SCHEMBL29511793 | 0.71 | HTT (0.59) | KMT2AMEN1ADRA2AADRA2BADRA2C | |
| SCHEMBL8824762 | 0.70 | MAPT (0.37) | KMT2AMEN1MAPTLMNA | |
| SCHEMBL15087184 | 0.69 | ADRA2A (0.64) | KMT2AMEN1METAP2ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747206-A1 | AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005111003-A1 | AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |