Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | NAAA | Q02083 | 3/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MLYCD | O95822 | 1/20 | 0.50 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535319 | 0.98 | SMN1; SMN2 (0.74) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL2972657 | 0.95 | SMN1; SMN2 (0.84) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL131829 | 0.91 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL6535127 | 0.91 | SMN1; SMN2 (0.87) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL2964483 | 0.89 | L3MBTL1 (0.69) | SMN1; SMN2NAAAL3MBTL1GAAALDH1A1 | |
| SCHEMBL28572321 | 0.89 | FAAH (0.62) | SMN1; SMN2NAAAL3MBTL1FAAH | |
| SCHEMBL16117373 | 0.87 | SMN1; SMN2 (1.00) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL10174301 | 0.86 | SMN1; SMN2 (0.79) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL13328782 | 0.86 | SMN1; SMN2 (0.79) | SMN1; SMN2NAAAL3MBTL1GAAMAPT | |
| SCHEMBL6536714 | 0.86 | NAAA (0.61) | SMN1; SMN2NAAAL3MBTL1MAPTCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |
| US-7176242-B2 | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-13 | — | — | US | disclosed |