Sugi Predict

Sugi Predict / Compounds / SCHEMBL5373079

SCHEMBL5373079

SCHEMBL5373079

O=C(c1ccc(C(F)(F)F)cc1)N1CCNCC1

nearest known ligand 0.74

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.71
▸ MEN1 O00255 1/20 0.71
▸ TSHR P16473 1/20 0.71
▸ KMT2A Q03164 1/20 0.71
▸ KCNH2 Q12809 2/20 0.62
▸ SIGMAR1 Q99720 2/20 0.62
▸ GAA P10253 1/20 0.60
▸ TDP1 Q9NUW8 1/20 0.60
▸ HSD11B1 P28845 1/20 0.56
▸ EPHX2 P34913 2/20 0.55
▸ MGLL Q99685 1/20 0.55
▸ GPR183 P32249 1/20 0.54
▸ MLYCD O95822 2/20 0.54
▸ SLC6A7 Q99884 1/20 0.53
▸ MKNK2 Q9HBH9 1/20 0.53
▸ MAOB P27338 1/20 0.52
▸ TEAD1 P28347 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13094484 0.94 HPGD (0.72) HPGDMEN1TSHRKMT2AKCNH2
Trifluoroacetic Acid SCHEMBL15565817 0.94 HPGD (0.63) HPGDMEN1TSHRKMT2AKCNH2
Hydrochloric Acid SCHEMBL3078193 0.93 HPGD (0.70) HPGDMEN1TSHRKMT2AKCNH2
SCHEMBL8358137 0.86 SIGMAR1 (0.81) HPGDSIGMAR1EPHX2MKNK2
SCHEMBL2686486 0.84 HPGD (0.96) HPGDMEN1TSHRKMT2ASIGMAR1
SCHEMBL270732 0.83 HPGD (0.97) HPGDMEN1TSHRKMT2ASIGMAR1
SCHEMBL9677283 0.83 HPGD (1.00) HPGDMEN1TSHRKMT2ASIGMAR1
SCHEMBL15244760 0.82 SCN9A (0.56) HPGDMEN1TSHRKMT2AKCNH2
SCHEMBL14223339 0.81 POLB (0.74) HPGDMEN1KMT2ASIGMAR1GAA
SCHEMBL28254884 0.81 MEN1 (0.73) HPGDMEN1TSHRKMT2ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108610280-A A kind of preparation method of bridged piperazine derivatives 湖南华腾制药有限公司 2018-10-02 — — CN claimed
CN-117820287-B Magnolol derivative, and preparation method and application thereof CHINA PHARMACEUTICAL UNIVERSITY (CN) 2026-05-26 — — CN disclosed
CN-119823089-A N-phenyl-2-azacyclic acetamide derivative, and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2025-04-15 — — CN disclosed
CN-117820287-A Magnolol derivative, and preparation method and application thereof 中国药科大学 2024-04-05 — — CN disclosed
US-20230183224-A1 BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2023-06-15 — — US disclosed
WO-2022130352-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA CADILA HEALTHCARE LIMITED (IN) 2022-06-23 — — WO disclosed
US-20200308158-A1 BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS HOFFMANN-LA ROCHE INC. (US) 2020-10-01 — — US disclosed
CN-108610280-A A kind of preparation method of bridged piperazine derivatives 湖南华腾制药有限公司 2018-10-02 — — CN disclosed
CN-108610280-A A kind of preparation method of bridged piperazine derivatives 湖南华腾制药有限公司 2018-10-02 — — CN disclosed
EP-2799435-B1 POLY (ADP-RIBOSE) POLYMERASE INHIBITOR CHENGDU DIAO PHARMACEUTICAL GROUP CO LTD (CN) 2018-03-28 — — EP disclosed
US-6306857-B1 INHIBITION OF ABNORMALLY PHOSPHORYLATED MOLECULAR GERIATRICS CORPORATION 2001-10-23 — — US disclosed
US-20010025105-A1 Certain substituted 1-aryl-3-piperazine-1'-yl propanones MOLECULAR GERIATARICS CORPORATION 2001-09-27 — — US disclosed
US-6214994-B1 TREATMENT OF NEOPLASTIC DISEASES, BACTERIAL OR FUNGAL INFECTIONS, AND PREVENTING OR DECREASING PRODUCTION OF PHOSPHORYLATED PAIRED HELICAL FILAMENT (PHF) EPITOPES ASSOCIATED WITH ALZHEIMER'S DISEASE MOLECULAR GERIATRICS CORPORATION 2001-04-10 — — US disclosed
US-6075026-A Certain substituted 1-aryl-3-piperazin-1'-yl propanones MOLECULAR GERIATRICS, CORP. (US) 2000-06-13 — — US disclosed
US-5693804-A USEFUL IN TREATING NEOPLASTIC DISEASES, BACTERIAL OR FUNGAL INFECTIONS AND ALZHEIMER'S DISEASE MOLECULAR GERIATRICS CORPORATION (US) 1997-12-02 — — US disclosed
EP-0792269-A2 CERTAIN SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES MOLECULAR GERIATRICS CORPORATION (US) 1997-09-03 — — EP disclosed
US-5658909-A INHIBITION OF ABNORMALLY PHOSPHORYLATED PAIRED HELICAL FILAMENT EPITOPE FORMATION MOLECULAR GERIATRICS CORPORATION (US) 1997-08-19 — — US disclosed
WO-1996015792-A9 METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE USING SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES — 1996-09-12 — — WO disclosed
WO-1996016052-A2 CERTAIN SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES MOLECULAR GERIATRICS CORPORATION (US) 1996-05-30 — — WO disclosed
WO-1996015792-A1 METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE USING SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES MOLECULAR GERIATRICS CORPORATION (US) 1996-05-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230183224-A1 BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS LPL, LIPC, PNLIP HPGD 2142/4885MEN1 2209/4885TSHR 1305/4885
US-20200308158-A1 BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS LPL, LIPC, PNLIP HPGD 2142/4885MEN1 2209/4885TSHR 1305/4885
US-20010025105-A1 Certain substituted 1-aryl-3-piperazine-1'-yl propanones PSEN1, PSEN2, PRNP HPGD 3121/4885MEN1 1720/4885TSHR 4412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.