Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 5/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5360267 | 0.88 | KMT2A (0.48) | CTRB1ADRB2SMN1; SMN2MEN1HTT | |
| SCHEMBL5360592 | 0.86 | KMT2A (0.43) | RAB9ANPC1CTRB1ADRB2SMN1; SMN2 | |
| SCHEMBL2472052 | 0.78 | CTRB1 (0.46) | RAB9ANPC1CTSLCTRB1CTSB | |
| SCHEMBL5363936 | 0.76 | KMT2A (0.44) | CTRB1ADRB2SMN1; SMN2MEN1HTT | |
| SCHEMBL2348792 | 0.75 | ATM (0.50) | CTSLCTSBCTSSCTSKKMT2A | |
| SCHEMBL5371067 | 0.75 | NPC1 (0.42) | RAB9ANPC1CTSLCTRB1HPGDS | |
| SCHEMBL10644950 | 0.75 | EPHX1 (0.47) | MEN1HTTKMT2A | |
| SCHEMBL5368445 | 0.74 | KMT2A (0.40) | RAB9ANPC1CTRB1ADRB2SMN1; SMN2 | |
| SCHEMBL8573972 | 0.72 | ATM (0.37) | MEN1KMT2A | |
| SCHEMBL5378282 | 0.71 | CTSL (0.42) | RAB9ANPC1CTSLCTRB1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |