Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5363936 | 0.94 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2HTTADRB2 | |
| SCHEMBL5360592 | 0.88 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2HTTADRB2 | |
| SCHEMBL5360267 | 0.81 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2HTTADRB2 | |
| SCHEMBL5374718 | 0.74 | RAB9A (0.41) | KMT2AMEN1SMN1; SMN2HTTADRB2 | |
| SCHEMBL5375114 | 0.73 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2HTTDPP4 | |
| SCHEMBL5370680 | 0.72 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2HTTDPP4 | |
| SCHEMBL5363812 | 0.69 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2HTTDPP4 | |
| SCHEMBL5367875 | 0.68 | KMT2A (0.40) | KMT2AMEN1SMN1; SMN2HTTDPP4 | |
| SCHEMBL5368717 | 0.68 | KMT2A (0.40) | KMT2AMEN1SMN1; SMN2HTTDPP4 | |
| SCHEMBL24604163 | 0.64 | SLC6A3 (0.46) | KMT2AMEN1SMN1; SMN2HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |