Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658615 | 0.89 | P4HTM (0.50) | P4HTMMAOAMAOBMEN1KMT2A | |
| SCHEMBL5376202 | 0.86 | P4HTM (0.48) | P4HTMMAOAMAOBMEN1KMT2A | |
| SCHEMBL5375510 | 0.84 | HRH3 (0.50) | P4HTMMAOBMEN1KMT2AKDM4C | |
| SCHEMBL5379438 | 0.81 | LMNA (0.48) | P4HTMMEN1KMT2AKDM4CMAPT | |
| SCHEMBL5380505 | 0.80 | HSD17B10 (0.42) | P4HTMMAOAMAOBMEN1KMT2A | |
| SCHEMBL5379659 | 0.80 | EGFR (0.44) | P4HTMMAOAMAOBMEN1KMT2A | |
| SCHEMBL5392310 | 0.80 | MMP1 (0.47) | P4HTMMAOBMEN1KMT2AKDM4C | |
| SCHEMBL5381466 | 0.80 | MAPK1 (0.46) | P4HTMMEN1KMT2AMAPTTNKS2 | |
| SCHEMBL5374989 | 0.80 | HRH3 (0.44) | P4HTMMAOAMAOBMEN1KMT2A | |
| SCHEMBL14400075 | 0.75 | HRH3 (0.50) | KMT2AKDM4CUSP2POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-7288545-B2 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2007-10-30 | — | — | US | disclosed |
| US-20040132738-A1 | Piperazinedione compounds | ANGIORX CORPORATION (TW) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132738-A1 | Piperazinedione compounds | CBR1, KDR, FLT1 | P4HTM 1191/4885AKT1 3148/4885MAOA 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.