Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848780 | 0.87 | CACNA1G (0.61) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL15522788 | 0.82 | CACNA1G (0.49) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL5848129 | 0.77 | MAPK1 (0.53) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL5848536 | 0.77 | MAPK1 (0.53) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL5849071 | 0.76 | MAPK1 (0.52) | CACNA1GCACNA1HCACNA1IHDAC1HDAC6 | |
| SCHEMBL5849947 | 0.76 | MAPK1 (0.52) | CACNA1GCACNA1HCACNA1IMAPTHDAC1 | |
| SCHEMBL5661589 | 0.75 | SIGMAR1 (0.57) | SIRT2SIRT1KDM4EALDH1A1MEN1 | |
| SCHEMBL29572755 | 0.75 | SIGMAR1 (0.57) | SIRT2SIRT1KDM4EALDH1A1MEN1 | |
| SCHEMBL30945858 | 0.75 | ALDH1A1 (0.48) | MAPTKDM4EFAAHALDH1A1MEN1 | |
| SCHEMBL29234305 | 0.75 | ALDH1A1 (0.48) | MAPTKDM4EFAAHALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343961-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| EP-2414361-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ArQule, Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114894-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-2010114894-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-10-07 | — | — | WO | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249115-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | CYP11B2, GABBR1, CNR1 | CACNA1G 868/4885CACNA1H 1274/4885CACNA1I 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.