SCHEMBL5376352

SCHEMBL5376352

Clc1nc(Cl)c2nc(Cl)[nH]c2n1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9194824 0.82
SCHEMBL12592351 0.77 CSNK2A1 (0.38)
SCHEMBL14347071 0.77 YTHDC1 (0.32)
SCHEMBL7526936 0.77 CDK1 (0.35) ALDH1A1
SCHEMBL10617981 0.77 CSNK2A2 (0.33) ALDH1A1
Hydrochloric Acid SCHEMBL31329224 0.76 CSNK2A1 (0.37)
SCHEMBL9937857 0.73 GAA (0.32)
SCHEMBL9937148 0.71 LMNA (0.31)
SCHEMBL18050702 0.71 CYP1A2 (0.33) ALDH1A1ALOX15
SCHEMBL18050703 0.71 KDM4E (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030191086-A1 Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof USTAV EXPERIMENTALNI BOTANIKY AV CR 2003-10-09 US claimed
EP-1147108-B1 SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF USTAV EX BOTAN AKADEMIE VED CE (CZ) 2003-08-13 EP claimed
EP-1147108-A1 SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF Ustav Experimentalni Botaniky Akademie ved Ceské Republiky (CZ) 2001-10-24 EP claimed
WO-2000043394-A1 SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF ÚSTAV EXPERIMENTÁLNÍ BOTANIKY AV CR (CZ) 2000-07-27 WO claimed
US-4134792-A Specific binding assay with an enzyme modulator as a labeling substance MILES LABORATORIES, INC. (US) 1979-01-16 US claimed
WO-2023092781-A1 PREPARATION METHOD FOR REVERSE OSMOSIS MEMBRANE, AND REVERSE OSMOSIS MEMBRANE PREPARED THEREBY 沃顿科技股份有限公司 2023-06-01 WO disclosed
CN-116159449-A Method for preparing reverse osmosis membrane and reverse osmosis membrane prepared by same 沃顿科技股份有限公司 2023-05-26 CN disclosed
US-20230104311-A1 NOVEL 6-SUBSTITUTED 7-DEAZAPURINES AND CORRESPONDING NUCLEOSIDES AS MEDICAMENTS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-04-06 US disclosed
EP-4106763-A1 NOVEL 6-SUBSTITUTED 7-DEAZAPURINES AND CORRESPONDING NUCLEOSIDES AS MEDICAMENTS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2022-12-28 EP disclosed
CN-115515593-A Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments 勒芬天主教大学 2022-12-23 CN disclosed
US-20070197533-A1 Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds ANADYS PHARMACEUTICALS, INC. (US) 2007-08-23 US disclosed
US-7223759-B2 Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds ANADYS PHARMACEUTICALS, INC. (US) 2007-05-29 US disclosed
WO-2000043394-A1 SUBSTITUTED NITROGEN HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL USE THEREOF ÚSTAV EXPERIMENTÁLNÍ BOTANIKY AV CR (CZ) 2000-07-27 WO disclosed
US-5756253-A PROCESSING OF DIFFUSION TRANSFER PHOTOGRAPHIC FILM UNITS IN PRESENCE OF HYPOXANTHINE AND INOSINE POLAROID CORPORATION (US) 1998-05-26 US disclosed
US-4724200-A CRYSTAL STRUCTURE EASTMAN KODAK COMPANY (US) 1988-02-09 US disclosed
US-4680255-A Emulsions and photographic elements containing silver halide grains having tetrahexahedral crystal faces EASTMAN KODAK COMPANY (US) 1987-07-14 US disclosed
US-4680256-A Emulsions and photographic elements containing silver halide grains having trisoctahedra crystal faces EASTMAN KODAK COMPANY (US) 1987-07-14 US disclosed
US-4680254-A Emulsions and photographic elements containing silver halide grains having hexoctamedral crystal faces EASTMAN KODAK COMPANY (US) 1987-07-14 US disclosed
US-4134792-A Specific binding assay with an enzyme modulator as a labeling substance MILES LABORATORIES, INC. (US) 1979-01-16 US disclosed
US-4001031-A CHLORINATED ORGANIC FUEL CONVERTS POTASSIUM OXIDE TO POTASSIUM CHLORIDE CHEM-TROL POLLUTION SERVICES, INC. (US) 1977-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030191086-A1 Substituted nitrogen heterocyclic derivatives and pharmaceutical use thereof CDK4, CDK5, CCNI ALDH1A1 4084/4885ALOX15 3898/4885TSHR 3907/4885
US-20070197533-A1 Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds DDC, DPP3, AMPD3 ALDH1A1 2233/4885ALOX15 2890/4885TSHR 4325/4885
US-20230104311-A1 NOVEL 6-SUBSTITUTED 7-DEAZAPURINES AND CORRESPONDING NUCLEOSIDES AS MEDICAMENTS ADA, ADAR, TPMT ALDH1A1 444/4885ALOX15 3059/4885TSHR 3631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.