Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | CCR3 | P51677 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5393257 | 0.83 | CCR3 (0.65) | ALDH1A1HTTUSP2TSHRHTR3E | |
| SCHEMBL5773446 | 0.83 | ALDH1A1 (0.62) | ALDH1A1HTTUSP2TSHRHTR3E | |
| Hydrochloric Acid SCHEMBL5382308 | 0.82 | CCR3 (0.64) | ALDH1A1HTTUSP2TSHRHTR3E | |
| SCHEMBL3292185 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HTTUSP2TSHRHTR3E | |
| SCHEMBL17512052 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HTTUSP2TSHRHTR3E | |
| Hydrochloric Acid SCHEMBL31587848 | 0.79 | USP2 (0.45) | ALDH1A1HTTUSP2TSHRCCR3 | |
| SCHEMBL16128201 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HTTUSP2TSHRHTR3E | |
| SCHEMBL5379016 | 0.78 | CCR3 (0.65) | ALDH1A1HTTCCR3MAPK1 | |
| SCHEMBL5383638 | 0.77 | CCR3 (0.74) | DRD2DRD3CCR3 | |
| SCHEMBL20685543 | 0.76 | ALDH1A1 (0.61) | ALDH1A1DRD2DRD4DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| US-7157471-B2 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-01-02 | — | — | US | disclosed |
| EP-1660476-B1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2006-12-27 | — | — | EP | disclosed |
| EP-1660476-A1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2006-05-31 | — | — | EP | disclosed |
| US-20050124659-A1 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| WO-2005019203-A1 | HALOALKYL- AND PIPERIDINE-SUBSTITUTED BENZIMIDAZOLE-DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124659-A1 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives | ABCB11, KCNJ11, CFTR | ALDH1A1 143/4885HTT 1228/4885USP2 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.