Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17512052 | 1.00 | ALDH1A1 (0.55) | ALDH1A1HTTUSP2TSHRCHRM1 | |
| SCHEMBL16128078 | 0.92 | HRH1 (0.51) | ALDH1A1HTTUSP2TSHRCHRM1 | |
| SCHEMBL17512051 | 0.92 | HRH1 (0.51) | ALDH1A1HTTUSP2TSHRCHRM1 | |
| SCHEMBL16100832 | 0.88 | HDAC1 (0.45) | ALDH1A1CHRM1HRH1DRD2DRD4 | |
| SCHEMBL16100833 | 0.88 | HDAC1 (0.45) | ALDH1A1CHRM1HRH1DRD2DRD4 | |
| SCHEMBL16102847 | 0.88 | DRD2 (0.46) | HTTUSP2TSHRDRD2DRD4 | |
| SCHEMBL16102848 | 0.88 | DRD2 (0.46) | HTTUSP2TSHRDRD2DRD4 | |
| SCHEMBL16127791 | 0.88 | OPRM1 (0.55) | TSHRCHRM1HRH1HTR3ADRD2 | |
| SCHEMBL17512053 | 0.88 | OPRM1 (0.55) | TSHRCHRM1HRH1HTR3ADRD2 | |
| SCHEMBL17512086 | 0.86 | TRPV4 (0.43) | ALDH1A1CHRM1HRH1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-9656994-B2 | Substituted benzimidazoles as nociceptin receptor modulators | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-02-25 | — | — | US | disclosed |
| WO-2014153529-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052913-A1 | SUBSTITUTED BENZIMIDAZOLES AS NOCICEPTIN RECEPTOR MODULATORS | OPRL1, OPRK1, OPRM1 | ALDH1A1 3423/4885HTT 157/4885USP2 2772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.