Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.71 |
| ▸ | TTK | P33981 | 2/20 | 0.71 |
| ▸ | ALPL | P05186 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17178615 | 0.84 | ALDH1A1 (0.92) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL30768403 | 0.84 | ALDH1A1 (1.00) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL855531 | 0.84 | ALDH1A1 (1.00) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL1672674 | 0.81 | IDO1 (0.78) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL4480025 | 0.81 | ALDH1A1 (0.71) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL5377572 | 0.81 | ALDH1A1 (0.71) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL12318475 | 0.81 | KDM4E (0.71) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL4200287 | 0.81 | IDO1 (0.71) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL28982378 | 0.81 | IDO1 (0.71) | IDO1KDM4EALDH1A1GAATTK | |
| SCHEMBL11685205 | 0.80 | MAP2K4 (0.50) | IDO1KDM4EALDH1A1GAATTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |