Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.48 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.48 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LATS1 | O95835 | 4/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PRKCH | P24723 | 2/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5394585 | 0.88 | CHEK1 (0.50) | BCHETRPC3TRPC4TRPC5CHEK1 | |
| SCHEMBL6034415 | 0.80 | BCHE (0.72) | BCHETRPC3TRPC4TRPC5TDP1 | |
| SCHEMBL9240666 | 0.76 | KDM4C (0.39) | KDM4CALDH1A1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4640893 | 0.76 | BCHE (0.70) | BCHETRPC3TRPC4TRPC5TDP1 | |
| SCHEMBL5376933 | 0.76 | PIM1 (0.43) | BCHETRPC3TRPC4TRPC5CHEK1 | |
| SCHEMBL5383267 | 0.75 | SLC2A1 (0.40) | BCHETRPC3TRPC4TRPC5TDP1 | |
| SCHEMBL6439777 | 0.75 | BCHE (0.68) | BCHETRPC3TRPC4TRPC5TDP1 | |
| SCHEMBL6034750 | 0.73 | PIM1 (0.41) | BCHETRPC3TRPC4TRPC5CHEK1 | |
| SCHEMBL24823072 | 0.73 | LATS1 (0.41) | CHEK1CHEK2LATS1LATS2HRH3 | |
| SCHEMBL13804704 | 0.73 | PIM1 (0.43) | BCHETRPC3TRPC4TRPC5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE, INC. (US) | 2007-09-13 | — | — | US | disclosed |
| US-7220757-B2 | Compositions and methods for topical administration of 2-NH-heteroarylimidazoles | REPLIDYNE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | BERGE JOHN | 2006-01-19 | — | — | US | disclosed |
| US-6943175-B2 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | REPLIDYNE, INC. | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147548-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | NSUN3, TRMT1, NOP2 | BCHE 2921/4885TRPC3 3042/4885TRPC4 4219/4885 |
| US-20070213362-A1 | 2-NH-HETEROARYLIMIDAZOLES WITH ANTIBACTERIAL ACTIVITY | MET, ASNS, MRPS22 | BCHE 1927/4885TRPC3 4800/4885TRPC4 4842/4885 |
| US-20060014748-A1 | 2-NH-heteroarylimidazoles with antibacterial activity | TRMT1, NSUN3, NOP2 | BCHE 2752/4885TRPC3 3033/4885TRPC4 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.