Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.38 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5379943 | 0.88 | HRH4 (0.44) | PIM1BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL5385517 | 0.79 | NUDT1 (0.49) | PIM1BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL5382890 | 0.73 | BCHE (0.48) | PIM1BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL5389979 | 0.73 | BCHE (0.55) | PIM1BCHETDP1STK17A | |
| SCHEMBL5388762 | 0.72 | PIM1 (0.45) | PIM1HRH3CHEK1CHEK2HSP90AA1 | |
| SCHEMBL6034415 | 0.71 | BCHE (0.72) | BCHETRPC3TRPC4TRPC5TSHR | |
| SCHEMBL5394585 | 0.71 | CHEK1 (0.50) | PIM1BCHETRPC3TRPC4TRPC5 | |
| Hydrochloric Acid SCHEMBL5373989 | 0.70 | SLC2A1 (0.38) | BCHETRPC3TRPC4TRPC5 | |
| SCHEMBL4640893 | 0.67 | BCHE (0.70) | BCHETRPC3TRPC4TRPC5TSHR | |
| SCHEMBL13804704 | 0.67 | PIM1 (0.43) | PIM1BCHETRPC3TRPC4TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-06-15 | — | — | US | disclosed |
| US-7030137-B2 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. (US) | 2006-04-18 | — | — | US | disclosed |
| EP-1603881-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | Replidyne, Inc. (US) | 2005-12-14 | — | — | EP | disclosed |
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | REPLIDYNE, INC. | 2005-01-13 | — | — | US | disclosed |
| WO-2004078119-A2 | SUBSTITUTED THIOPHENES WITH ANTIBACTERIAL ACTIVITY | REPLIDYNE INC. (US) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009833-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | PIM1 2474/4885BCHE 1197/4885TRPC3 3505/4885 |
| US-20060128735-A1 | Substituted thiophenes with antibacterial activity | TST, MTR, NSUN3 | PIM1 2474/4885BCHE 1197/4885TRPC3 3505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.