Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethenzamide SCHEMBL25624 | 0.93 | MAPT (0.68) | MAPTMEN1KMT2ALMNANR1I2 | |
| Ethenzamide SCHEMBL27612766 | 0.93 | MAPT (0.68) | MAPTMEN1KMT2ALMNANR1I2 | |
| Ethenzamide SCHEMBL4379591 | 0.91 | MAPT (0.66) | MAPTMEN1KMT2ALMNANR1I2 | |
| Ethenzamide SCHEMBL22163775 | 0.91 | MAPT (0.66) | MAPTMEN1KMT2ALMNANR1I2 | |
| Ethenzamide SCHEMBL5401172 | 0.91 | MAPT (0.66) | MAPTMEN1KMT2ALMNANR1I2 | |
| Formic Acid SCHEMBL5396723 | 0.87 | LMNA (0.70) | MAPTMEN1KMT2ALMNANR1I2 | |
| SCHEMBL7932427 | 0.83 | MEN1 (0.60) | MAPTMEN1KMT2ALMNANR1I2 | |
| Ethenzamide SCHEMBL14977210 | 0.83 | HTT (0.60) | MAPTMEN1KMT2ALMNANR1I2 | |
| SCHEMBL23041012 | 0.80 | MAPT (0.53) | MAPTMEN1KMT2ALMNANR1I2 | |
| SCHEMBL1829556 | 0.80 | LMNA (0.60) | MAPTMEN1KMT2ALMNANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | disclosed |
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025459-A1 | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | BACE2, PSEN2, BACE1 | MAPT 16/4885MEN1 586/4885KMT2A 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.