Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5376093 | 0.82 | GSK3B (0.63) | CDC7GSK3BKMT2APDE10ACDK2 | |
| SCHEMBL5383563 | 0.79 | GSK3B (0.70) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5386907 | 0.78 | GSK3B (0.48) | MAPTLMNASMN1; SMN2CDC7GSK3B | |
| SCHEMBL5380263 | 0.78 | GSK3B (0.48) | CDC7GSK3BKMT2APDE10APIK3C3 | |
| SCHEMBL5380257 | 0.78 | MAPT (0.49) | KDM4EMAPTLMNASMN1; SMN2CDC7 | |
| SCHEMBL5386527 | 0.77 | GSK3B (0.53) | CDC7GSK3BPDE10ACDK2HRH3 | |
| SCHEMBL5391617 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5376071 | 0.76 | GSK3B (0.49) | CDC7GSK3BPDE10ACCNE2CDK4 | |
| SCHEMBL5399975 | 0.76 | CDC7 (0.48) | SMN1; SMN2CDC7GSK3BCDK2 | |
| SCHEMBL5390682 | 0.76 | GSK3B (0.64) | ALDH1A1MAPTSMN1; SMN2CDC7GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |