Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.79 |
| ▸ | RORC | P51449 | 16/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372049 | 0.96 | HTR6 (0.85) | HTR6RORCDRD2SLC6A4SCN9A | |
| Oxalic Acid SCHEMBL5379663 | 0.94 | HTR6 (0.78) | HTR6RORCDRD2SLC6A4SCN9A | |
| SCHEMBL5767852 | 0.86 | HTR6 (0.72) | HTR6DRD2SLC6A4 | |
| SCHEMBL5371232 | 0.86 | HTR6 (0.71) | HTR6DRD2 | |
| SCHEMBL5770874 | 0.85 | HTR6 (0.70) | HTR6DRD2SLC6A4 | |
| SCHEMBL5771470 | 0.85 | HTR6 (0.70) | HTR6RORCDRD2 | |
| Hydrochloric Acid SCHEMBL5371228 | 0.85 | HTR6 (0.70) | HTR6DRD2 | |
| SCHEMBL21572776 | 0.84 | HTR6 (0.66) | HTR6RORCDRD2SLC6A4SCN9A | |
| Oxalic Acid SCHEMBL5375349 | 0.84 | HTR6 (0.66) | HTR6DRD2SLC6A4 | |
| Oxalic Acid SCHEMBL6649675 | 0.84 | HTR6 (0.63) | HTR6RORCDRD2SLC6A4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7230011-B2 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht6 receptor | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | claimed |