SCHEMBL538460

SCHEMBL538460

CC(C)(C)c1ccc(-c2cc(O)c(C(C)(C)C)cc2C(=O)O)c(C(C)(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
ALDH1A1 P00352 3/20 0.40
MAPT P10636 3/20 0.40
ALOX15 P16050 2/20 0.40
KDM4E B2RXH2 2/20 0.40
CYP1A2 P05177 1/20 0.40
ATP2A2 P16615 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ATP2A3 Q93084 1/20 0.40
AKR1C2 P52895 1/20 0.40
AKR1C1 Q04828 1/20 0.40
HSD17B10 Q99714 2/20 0.40
HPGD P15428 1/20 0.40
PTPN5 P54829 1/20 0.39
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA9 Q16790 1/20 0.38
MEN1 O00255 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6844262 0.82 TDP1 (0.46) TDP1ALDH1A1ALOX15AKR1C2AKR1C1
SCHEMBL7132396 0.79 ALDH1A1 (0.47) TDP1ALDH1A1ALOX15KDM4ECA12
SCHEMBL8687536 0.78 HNF4A (0.47) TDP1ALDH1A1KDM4EAKR1C2AKR1C1
SCHEMBL27904859 0.77 TDP1 (0.56) TDP1ALDH1A1ALOX15KDM4ESMN1; SMN2
SCHEMBL4631399 0.77 TDP1 (0.59) TDP1ALDH1A1ALOX15KDM4ESMN1; SMN2
SCHEMBL4201442 0.76 AKR1C2 (0.43) TDP1ALDH1A1MAPTALOX15KDM4E
SCHEMBL93460 0.76 GLRA3 (0.41) TDP1MAPTKDM4ECYP1A2AKR1C2
SCHEMBL18690280 0.76 TDP1 (0.48) TDP1ALDH1A1SMN1; SMN2AKR1C2AKR1C1
Bicarbonate SCHEMBL18315853 0.76 ALDH1A1 (0.57) TDP1ALDH1A1MAPTALOX15KDM4E
SCHEMBL27888034 0.76 TDP1 (0.57) TDP1ALDH1A1ALOX15KDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173343-B2 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH COMPANY, LTD. (JP) 2012-05-08 US disclosed
EP-2146251-B1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH CO LTD (JP) 2012-02-08 EP disclosed
US-20100015538-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS USING THE SAME, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2010-01-21 US disclosed
EP-2146251-A1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge Ricoh Company, Ltd. (JP) 2010-01-20 EP disclosed
EP-0768354-B1 Sheet for protecting paint films of automobiles NITTO DENKO CORP (JP) 2001-01-10 EP disclosed
US-6030702-A FOR PROTECTING PAINT FILMS OF AUTOMOBILES FOR ADHERING TO INCOMPLETELY CURED PAINT FILMS OF AUTOMOBILES COMPRISING A TWO PACK URETHANE PAINT, SAID SHEET COMPRISING A SUPPORT AND A PRESSURE-SENSITIVE ADHESIVE LAYER FORMED THEREON NITTO DENKI CORPORATION (JP) 2000-02-29 US disclosed
EP-0768354-A2 Sheet for protecting paint films of automobiles NITTO DENKO CORPORATION (JP) 1997-04-16 EP disclosed